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Year : 2003  |  Volume : 69  |  Issue : 4  |  Page : 277--280

Safety and efficacy of adapalene gel 0.1% in acne vulgaris: Results of a post-marketing surveillance study

Galderma India Pvt. Ltd., Mumbai., India

Correspondence Address:
S H Percy
Galderma India Pvt. Ltd., 23, Steelmade Industrial Estate, 2nd Floor, Marol Village, Andheri (E), Mumbai - 400059
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Source of Support: None, Conflict of Interest: None

PMID: 17642911

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Introduction: Adapalene is a novel retinoid indicated for the topical treatment of acne vulgaris. The drug was introduced in India in 2001. Aims: A post-marketing surveillance study was conducted to assess the safety and efficacy of adapalene gel 0.1% when used as monotherapy or in combination with other anti-acne agents in Indian patients of acne vulgaris. Material and Methods: A 12-week, multicentre, open-label, non-comparative study involving 571 patients from 21 centers across India was conducted between January and September of 2002. Concomitant prescription of other anti-acne drugs was permitted, if needed. Results: Of the 571 patients, 441 completed the treatment as per protocol. At the end of therapy, 96.3% of patients showed an improvement in their acne from baseline, with greater than 75% improvement seen in two-thirds of patients. Adverse events were reported in 24% of the patients, none of which were serious. The tolerability of therapy was rated as excellent/good in 81% of patients by physicians and in 78% by the patients. Conclusion: Adapalene gel 0.1% is a safe and effective topical agent in the treatment of mild to moderate acne vulgaris in Indian patients. It may be safely combined with other topical and oral anti-acne agents.


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Online since 15th March '04
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