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Year : 2003  |  Volume : 69  |  Issue : 3  |  Page : 209--211

Diltiazem vs. nifedipine in chilblains: A clinical trial

Department of Dermatology, STD & Leprosy, Military Hospital, Agra, India, India

Correspondence Address:
A K Patra
Department of Dermatology Military Hospital, Agra Cantt-282001.
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Source of Support: None, Conflict of Interest: None

PMID: 17642888

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Background: The treatment of chilblains remains unsatisfactory. Nifedipine in higher doses remains the mainstay of treatment. Aims: To compare the efficacy of diltiazem with that of nifedipine, and to determine the efficacy of nifedipine in lower doses, 36 chilblains cases were studied. Material and Methods: Group A (12 patients) was treated with diltiazem 60 mg thrice daily, and Group B (24 patients) with 10 mg nifedipine thrice daily till complete relief and then maintained on a sustained release preparation of nifedipine 20 mg twice daily. Results: Two patients in Group A showed complete relief in 7 days, and 3 patients in about 21 days, but in 7 cases there was little or no response. In group B, 21 cases showed 80-90% relief by the fourteenth day. Conclusions: We conclude that nifedipine remains the drug of choice in chilblains but can be used in a smaller dosage in the Indian population. Diltiazem is less effective in the conventional dose, which may be optimized.


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Online since 15th March '04
Published by Wolters Kluwer - Medknow