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 ORIGINAL ARTICLE
Year : 2003  |  Volume : 69  |  Issue : 2  |  Page : 168--169

Role of anti-depressant fluoxetine in the puva treatment of psoriasis vulgaris


1 Ruby General Hospital, Kolkata - 78, India
2 Advanced Skin Treatment Centre, Kolkata - 19, India
3 VIMS, Sarat Bose Road, Kolkata - 29, India

Correspondence Address:
A Mitra
PO Box 16211, Kolkata - 29
India
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Source of Support: None, Conflict of Interest: None


PMID: 17642869

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Severity of Psoriasis Vulgaris is known to be modified by psychological stress. The objective of this study was to evaluate the role of Fluoxetine in the PUVA treatment of Psoriasis. Twenty patients with progressive disease having more than thirty per cent body area involvement were included in a randomized, double blinded, placebo-controlled, age and sex matched study. All patients were on PUVAtreatment; half of the patients were given Fluoxetine 20 mgms daily whereas the other ten were given placebo. Assessment was done by Psoriasis Area and Severity Index (PASI) scoring after every 5 exposures of PUVA treatment till 20 treatments. All ten patients who took Fluoxetine along with PUVA treatment showed better response and quicker remission. Fluoxetine may be used as an adjuvant in PUVA treatment of Psoriasis.






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Online since 15th March '04
Published by Wolters Kluwer - Medknow