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 ORIGINAL ARTICLE
Year : 2003  |  Volume : 69  |  Issue : 2  |  Page : 135--137

The efficacy of low-dose oral corticosteroids in the treatment of vitiligo patient


Dept. of Dermatology, STD, Community Medicine, Nilratan Sarkar Medical College, Kolkata, India

Correspondence Address:
J N Barbhuiya
81, Banerjeepara Road, Kolkata - 41
India
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Source of Support: None, Conflict of Interest: None


PMID: 17642858

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Autoimmunity is one of the most probable pathogenesis of vitiligo. Systemic corticosteroids may arrest the progression of vitiligo and lead to repigmentation by suppressing immunity. The clinical efficacy of low-dose oral corticosteroids was assessed to minimize the side-effects in actively spreading vitiligo patients. One hundred (100) patients with vitiligo were evaluated. The patients took daily doses of oral prednisolone (0.3mg/kg body weight) initially as a single oral dose after breakfast for the first 2 months. The dosage was then reduced to half the initial dose during the 3rd month and was halved again for the 4th and final month. After 4 months of treatment, 76% showed repigmentation while the arrest of progression (both repigmentation and stationary) was noted in 90% of patients. Male sex, and patients under 15 years of age showed pronounced repigmentation with statistical significance. According to this study low-dose oral prednisolone is an effective method in preventing progression and inducing repigmentation of fast-spreading vitiligo without the associated serious side-effects.






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Online since 15th March '04
Published by Wolters Kluwer - Medknow