Indexed with PubMed and Science Citation Index (E) 
Users online: 2201 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  Navigate here 
   Next article
   Previous article 
   Table of Contents
 Resource links
   Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   [PDF Not available] *
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

  In this article
    Case Report

 Article Access Statistics
    PDF Downloaded1    
    Comments [Add]    

Recommend this journal

Year : 2002  |  Volume : 68  |  Issue : 5  |  Page : 295

Rare sequelae of herpes zoster in HIV positive patient

Department of Skin and VD KMC, Mangalore - 575 001, India

Correspondence Address:
Department of Skin and VD KMC, Mangalore - 575 001, India


A 34 year -old woman, who was diagnosed to be HIV positive 4 years back, presented with zoster along T-6 dermatome followed by development of keloid.

How to cite this article:
Goel SK, Kuruvila M. Rare sequelae of herpes zoster in HIV positive patient. Indian J Dermatol Venereol Leprol 2002;68:295

How to cite this URL:
Goel SK, Kuruvila M. Rare sequelae of herpes zoster in HIV positive patient. Indian J Dermatol Venereol Leprol [serial online] 2002 [cited 2020 Aug 3];68:295. Available from:

   Introduction Top

Herpes zoster commonly occurs early in the course of HIV infection. Post herpetic neuralgia, recurrences,[1],[4] disseminated zoster,[2] ulcerated lesions[3] and chronic verrucous lesions[1],[4] have been described in HIV infected patients with herpes zoster. To the best of our knowledge keloid following herpes zoster in HIV positive patient has not been reported.

   Case Report Top

A 34 - year -old woman, who was diagnosed to be HIV - positive in 1996, presented with herpes zoster along the T-6 dermatome on right side in June 1999. She was treated with acyclovir 800 mg five times a day for seven days. Lesions healed completely within a month. Patient observed itchy raised lesions along the post herpetic scar after two months. There was no history suggestive of post herpetic neuralgia or other features of opportunistic infections. On examination, keloid with linear distribution along the affected dermatome was seen. There was no evidence of keloid any where else on the body.

   Discussion Top

Herpes zoster appears between two and seven years after seroconversion, usually while the patient is asymptomatic. It follows a course similar to that seen in healthy people and lesions often resolve without specific therapy. The capacity of immune system to react and the rapidity of such reactions determine the severity of infection beyond the initial ganglion - nerve - dermatome unit. The immune response may, in the process of eliminating virus, also contribute to tissue damage, augmenting cell lysis acutely and enhancing subsequent fibrosis and scarring.[5] The development of keloid in lesions of herpes zoster suggests that the related immunological process is still functioning in HIV positive patient. 

   References Top

1.Jacobson MA, Berger TG, Fikrig S, et al. Acyclovir resistant varicella zostervirus infection after chronic oral acyclovir therapy in patients with the acquired immuno deficiency syndrome (AIDS). Ann Intern Med 1990;112:187-191.  Back to cited text no. 1    
2.Cohen PR, Beltrani VP, Grossman ME. Disseminated herpes zoster in patients with human immunodeficiency virus infection. Am J Med 1988; 84: 1076 - 1080.  Back to cited text no. 2    
3.Gilson IH, Barnett JH, Conant MA, et al. Disseminated ecthymotous herpes varicella - zoster virus infection in patients with acquired immunodeficiency syndrome. J Am Acad Dermatol 1989; 20: 637 -642.  Back to cited text no. 3    
4.Pahwa S, Biron K, Lim W, et al. Continuous varicella zoster infection associated with acyclovir resistance in a child with AIDS. JAMA 1988; 260: 2879 - 2882.  Back to cited text no. 4    
5.Price RW. Herpes zoster. Med Clin North America 1982;66: 1105 - 1118.  Back to cited text no. 5    


Print this article  Email this article
Previous article Next article


Online since 15th March '04
Published by Wolters Kluwer - Medknow