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Year : 2002  |  Volume : 68  |  Issue : 4  |  Page : 225--226

Sezary syndrome - Without erythroderma


Department of Dermatology and Venereology Medical College, Trivandrum, Kerala, India

Correspondence Address:
K Abdul Samad
Department of Dermatology and Venereology Medical College, Trivandrum, Kerala
India
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Source of Support: None, Conflict of Interest: None


PMID: 17656944

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Sezary syndrome (SS), is described as the classical triad of pruritic erythroderma, lymphadenopathy, and presence of more than 10% of circulating Sezary cells in the peripheral blood. We report on unusual case of advanced cutaneous T - cell lymphoma with classical haematological and histopathological features of Sezary syndrome, but lacking the clinical features of erythroderma. A 66 year old man presented with asymptomatic multiple papules, plaques and nodules and with generalized lymphadenopathy. Peripheral smear showed more than 60% of Sezary cells. Skin and lymph node biopsy showed typical features of T-cell lymphoma and immunohistochemistry and CD marker studies showed the cells to be atypical T-lymphocytes. This unusual case is highlighted to denote that erythroderma need not be taken as a hard and fast criterion for diagnosing Sezary syndrome.






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Online since 15th March '04
Published by Wolters Kluwer - Medknow