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 ORIGINAL ARTICLE
Year : 2002  |  Volume : 68  |  Issue : 2  |  Page : 67--72

Acanthosis nigricans: A dermatologic marker of metabolic disease


1 Department of Endocrinology, TN Medical College &BYL Nair Ch. Hospital, Mumbai - 400 008, India
2 Department of Dermatology, TN Medical College &BYL Nair Ch. Hospital, Mumbai - 400 008, India
3 Dept, of Endocrinology, TN Medical College & BYL Nair Ch. Hospito, Mumbai - 400 008, India

Correspondence Address:
K D Nihalani
Dept, of Endocrinology, TN Medical College & BYL Nair Ch. Hospito, Mumbai - 400 008
India
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Source of Support: None, Conflict of Interest: None


PMID: 17656880

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Most patients with acanthosis nigricans have either clinical or subclinical insulin resistance. We undertook a study to estimate the insulin sensitivity of a group of patients referred from the dermatologist with biopsy proven acanthosis nigricans. Thirty- six patients were evaluated in the Endocrinology clinic. Plasma glucose and serum Insulin levels were estimated after a 75 gms oral glucose load (OGTT). An intravenous Insulin Tolerance Test (ITT) was performed with measurement of Glucose Disposal Rate (GDR). There were 28 females and 8 males (M:F - 3.5:1; mean age 26.3+/-1.7 years) in the study. 25/36 patients were morbidly obese (BMI-36.0 +/- 1.2 Kg/m2) with an abnormal body fat distribution (WH ratio - 0.9 +/ - 0.02). One patient had generalized lipoatrophy. 16/36 patients with acanthosis nigricans had IGT or overt diabetes and all had highly significant hyperinsulinemia (AUCI= 20825 +/ 1287.7 vs. 6340.0+/- 984.2 mIU/ml/hr in controls, p < 0.0005). The GDR in patients with acanthosis nigricans was reduced (-0.66+/-0.07) compared to controls (-0.39+/- 0.08; p < 0.01). There was a significant positive correlation between indices of adiposity and insulin resistance in subjects with impaired tolerance.






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