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 ORIGINAL ARTICLE
Year : 2002  |  Volume : 68  |  Issue : 1  |  Page : 28--32

Frictional amyloidosis in Oman - A study of ten cases


1 Department of Dermatology & Genito Urinary Medicine, Al Nahdha Hospital and Baushar Polyclinic, Muscat, Bahrain
2 Department of Pathology, College of Medicine, Sultan Qaboos University, Muscat, Oman

Correspondence Address:
Venkataram Mysore
Salmaniya Medical Complex, PB 12, Manama
Bahrain
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Source of Support: None, Conflict of Interest: None


PMID: 17656864

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Macular amyloidosis is an important cause for cutaneous pigmentation, the aetiology of which is poorly understood. Friction has recently been implicated the causation of early lesions, referred to as frictional amyloidosis. Confirmation of diagnosis by the detect on of amyloid using histochemical stains is inconsistent. Ten patients with pigmentation suggestive of macular amyloidosis were studied with detailed history, clinical examination, biopsy for histochemistry and electron microscopy. Nine out of ten patients had a history of prolonged friction with various objects such as bath sponges, brushes, towels, plant sticks and leaves. Amyloid was demonstrated by histochemical staining in only six out of ten cases. In the remaining four cases, amyloid was detected by electron microscopy. These consisted of aggregates of non-branching, extracellular, intertwining fibres measuring between 200-500 nm in length and between 20-25 nm in diameter. The study confirms the role of friction in the causation of this condition. Histochemical stains are not always successful in the detection of amyloid and electron microscopy is helpful for confirming its presence. The term frictional amyloidosis aptly describes the condition.






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Online since 15th March '04
Published by Wolters Kluwer - Medknow