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Year : 2001  |  Volume : 67  |  Issue : 6  |  Page : 317--319

Anticonvulsant hypersensitivity syndrome study of 60 cases

Department of Dermatology, STD and Leprosy, S.M.S. Medical College, Jaipur-302 004, India

Correspondence Address:
Puneet Bhargava
C-32, Peeyuslh Path, Bapu Nagat, Jaipur
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Source of Support: None, Conflict of Interest: None

PMID: 17664787

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Sixty patients of anticonvulsant hypersensitivity syndrome were studied. Fever and skin rash were present in all patients with peripheral blood leucocytosis and eosinophilia in 30 patients. Phenytoin was the commonest offending drug(39 patients) followed by carbamazepine (19 patients). AHS appeared after 2-12 weeks of the intake of offending drugs. Head injury was the primary illness in 43 patients (70 per cent) followed by brain tumors (9 patients). Cross reactivity between phenytoin and carbamazepine was seen in 3 patients. Most patients recovered well with withdrawal of the offending drugs and treatment with topical corticosteroids and antihistamines. There was only one fatality.

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Online since 15th March '04
Published by Wolters Kluwer - Medknow