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 ORIGINAL ARTICLE
Year : 2001  |  Volume : 67  |  Issue : 6  |  Page : 312--316

Endogenous sodium potassium ATPase inhibition related biochemical cascade and the acquired immunodeficiency syndrome -Neural regulation of viral replication and immune response to the virus


1 Dept. of Neurology, Medical College, Trivandrum, India
2 Dept. of Biochemistry, University of Kerala, Trivdndrum, India

Correspondence Address:
P A Kurup
Department of Biochemistry, University of Kerala, Gown Sadan, T.C. 4/1525, North of Cliff House, Kattu Road, Kowdiar, Trivandrum - 3, Kerala
India
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Source of Support: None, Conflict of Interest: None


PMID: 17664786

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The isoprenoid pathway and its metabolites - digoxin, dolichol and ubiquinone were assessed in acquired immunodeficiency syndrome. Digoxin is an endogenous regulator of membrane Na+-K+ ATPase secreted by the human hypothalamus. The HMG CoA reductase activity was increased with increased digoxin and dolichol levels and reduced ubiquinone levels in AIDS. Membrane Na+-K+ ATPase activity and serum magnesium levels were reduced. The tryptophan catabolites were increased and the tyrosine catabolites were reduced. The glycoconjugate metabolites were increased and lysosomal stability was reduced. There was reduced incorporation of glycoconjugates into membranes and increased membrane cholesterol: phospholipid ratio. Lipid peroxidation products and NO were increased while free radical scavenging enzymes and reduced glutathione were reduced. The role of the isoprenoid pathway related cascade in the pathogenesis of AIDS is discussed.






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Online since 15th March '04
Published by Wolters Kluwer - Medknow