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Year : 2000  |  Volume : 66  |  Issue : 6  |  Page : 328-329

Syringocystadenoma Papilliferum At Unusual Sites

Correspondence Address:
Apra Sood

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Source of Support: None, Conflict of Interest: None

PMID: 20877121

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We describe two cases in which syringocystadenoma papilliferum was present in extremely unusual locations.

Keywords: Syringocystadenoma papilliferum, Nevus sebaceous

How to cite this article:
Sood A, Khanna N, Kumar R. Syringocystadenoma Papilliferum At Unusual Sites. Indian J Dermatol Venereol Leprol 2000;66:328-9

How to cite this URL:
Sood A, Khanna N, Kumar R. Syringocystadenoma Papilliferum At Unusual Sites. Indian J Dermatol Venereol Leprol [serial online] 2000 [cited 2020 Sep 19];66:328-9. Available from:

  Introduction Top

Syringocystadenoma papilliferum is a proliferating skin tumor with apocrine differentiation in most of the cases and occasionally with eccrine differentiation.[1] The majority are seen on the face and scalp of young adults,often increasing in size at or around puberty.The lesion may be present at birth or appear in early childhood, but may also appear at a later age.[2] Histologically, there are characteristic duct-like structures covered by two layers of glandular epithelial cells,located in the upper dermis, with a varying degree of papillomatosis.[2] An infiltrate of plasma cells is seen in the stroma, especially in the papillary projections.We report two cases of syringocystadenoma papilliferum having characteristic morphology with distribution at unusual sites.

  Case Report Top

Case I

A. 5 -near- old boy presented with asymptomatic lesions in the right axilla that had been present since birth. Examination revealed a 2x 10 cm. linear plaque consisting of multiple skin coloured to yellowish, soft to firm, smooth papules coalescing in some areas [Figure - 1]. A few lesions had a central depression. Histopathological examination revealed papillomatosis and multiple cystic structures in the dermis lined by a double layer of epithelium, with a plasma cell infiltrate in the stroma.

Case II

A 20- year-old man presented with asymptomatic lesions on the anterior aspect of the neck since early childhood. There was a history of appearance of new lesions at puberty that he had attempted to burn, leading to infection and scarring. When presenting to us he had an irregular, erythematous, 6 cm plaque on the neck with multiple firm, hemispherical, coalescing papules on the surface and scarring in some areas [Figure - 2]. Histopathology sections showed cystic structures with papillary projections lined by a double layer of epithelium embedded in fibrous stroma with a scanty chronic inflammatory infiltrate.

  Discussion Top

Syringocystadenoma papilliferum is commonly seen on the scalp or face. In two large series[2],[3] scalp lesions were seen in more than half the cases. Less frequently reported sites are face, chest, abdomen, arm,[4] thighs and perineum.[2] Lesions may be present in a linear arrangement or as a solitary plaque.[4] The tumor is of an apocrine origin, with the cells lining the lumina showing evidence of decapitation secretion.[1] The cystic invaginations can also be seen to have connections with apocrine glands deep in the dermis. However, there are some lesions with eccrine differentiation too.[5]

Syringocystadenoma papilliferum is known to be associated with nevus sebaceous in about a third of the cases.[2] There may be associated malformed sebaceous glands and hair structures seen histopathologically. A basal cell epithelioma may develop in about 10% of cases[2], but this is seen only in lesions associated with a nevus sebaceous.

We consider that though well described, syringocystadenoma papilliferum is not a common tumour and axilla and neck are definitely uncommon sites.

  References Top

1.Lever WF. Pathogenesis of benign tumours of cutaneous appendages and of basal cell epithelioma. Arch Dermatol Syphilol 1948; 57:679-724.  Back to cited text no. 1    
2.Helwig EB, Hackney VC. Syringoadenoma papilliferum. Arch Dermatol 1995; 71: 361- 372.  Back to cited text no. 2    
3.Pinkus H. Life history of syringadenomatous papilliferous. Arch Dermatol Syphilol 1954; 63: 305- 322.  Back to cited text no. 3    
4.Rostan SE, Waller JD. Syringocystadenoma papilliferum in an unusual location. Arch Dermatol 1976; 112: 835- 836.  Back to cited text no. 4    
5.Elder D, Elenistas R, Ragsdale D. Tumours of the epidermal appendages. In, Elder D, Elenistas R, Jaworsky C, et al. Eds. Lever's Histopathology of the skin 8 Ed. Lippincott Raven Philadelphia 1997; 771-773.  Back to cited text no. 5    


[Figure - 1], [Figure - 2]


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