|LETTER TO EDITOR
|Year : 2000 | Volume
| Issue : 2 | Page : 107
Dexamethasone pulse for generalized lichen planus
J S Pasricha
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Pasricha J S. Dexamethasone pulse for generalized lichen planus. Indian J Dermatol Venereol Leprol 2000;66:107
To the Editor
The article published in the Indian J Dermatol Venereol Leprol 1998;64:103 by Mittal et al was interesting. I wish to inform your readers that we have used dexamethasone pulse therapy for several serious and/or generalized skin diseases including lichen planus. This has been mentioned in our recent publication, Pulse Therapy in Pemphigus and Other Diseases, 1998 edited by me. We however use 100 mg dexamethasone for 3 consecutive days, and repeat such pulses at 28-day intervals. The results are excellent. Interestingly, in spite of the very high dose of dexamethasone there are no side effects attributable to the corticosteroid.
Several patients however, especially those who are afraid of the pricks, prefer to take oral treatment. The oral treatment for lichen planus should consist of 2.0mg betamethasone taken as a single oral dose with the morning breakfast daily for 1 month, by which time all the lichen planus lesions regress completely. Thereafter, the dose is to be reduced by 0.5mg per month. The total treatment lasts 4 month. The relapse rate after this course is negligible (less than10%) and the side effects experienced during this period are by and large reversible. Any regimen less than that increases the chance of a relapse.
| References|| |
|1.||Pasricha J S. Lichen planus.In: Treatment of Skin Diseases. 4th Ed Oxford and IBH, New Delhi, 1991;190-193. |