Indexed with PubMed and Science Citation Index (E) 
Users online: 3317 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  Navigate here 
   Next article
   Previous article 
   Table of Contents
 Resource links
   Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   [PDF Not available] *
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

  In this article
   To the Editor:

 Article Access Statistics
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal


Year : 1999  |  Volume : 65  |  Issue : 6  |  Page : 302-303

Dapsone syndrome in pure neuritic hansen's disease

Correspondence Address:
V Rajkumar

Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 20921698

Rights and PermissionsRights and Permissions

How to cite this article:
Rajkumar V. Dapsone syndrome in pure neuritic hansen's disease. Indian J Dermatol Venereol Leprol 1999;65:302-3

How to cite this URL:
Rajkumar V. Dapsone syndrome in pure neuritic hansen's disease. Indian J Dermatol Venereol Leprol [serial online] 1999 [cited 2019 Oct 17];65:302-3. Available from: http://www.ijdvl.com/text.asp?1999/65/6/302/4850

  To the Editor: Top

A 35-year-old lady presented with history of high grade fever, chills and skin rashes of one week duration. History revealed irregular treatment with dapsone and rifampicin for the past 2-3 months for recurrent bulla on the left middle finger.

On examination patient was febrile with maculopapular eruption, mild edema of the face and limbs. Tender generalised lymphadenopathy and tender, hepatomegaly without icterus were noticed. She had a non healing ulcer over the left middle finger. Wasting of interossei and hypothenar muscles were obvious. Ulnar nerve was thickened and tender on the left side with impairment of sensation over the medial half of the palm.

Patient had anemia with Hb 7.5 gms %. Bile salts, bile pigments and renal function tests were normal. A diagnosis of pure neuritic Hansen's disease with dapsone syndrome was made and dapsone was stopped. Systemic steroids reduced the signs and symptoms. Five days later dapsone accidentally given to the patient by the junior doctor, resulted in flare up of skin lesions, fever and lymphadenopathy. Patient recovered fully with systemic steroid which was tapered gradually. Clofazimine and rifampicin were given for six months. Patient did not have any lesions and the bulla failed to reappear even after six months of follow up.

Dapsone syndrome is a type of hypersensitivity to dapsone which occurs after 4-6 weeks of therapy, the exact mechanism of which is not known.[1] The incidence is reported to be rare and declining.[2] It is reported in the treatment of Hansen's disease (PB and MB) and other dermatoses where dapsone is used.[3] This case is of interest because it is rare and still rarer in pure neuritic Hansen's disease. Also the therapy of Hansen's disease following dapsone syndrome with only clofazimine and rifampicin in this case is note worthy.

  References Top

1.Rochardus JH, Smith TC. Increased incidence in leprosy hypersensitivity reactions to dapsone after introducing MDT. Lepr Rev 1989;60:267-273  Back to cited text no. 1    
2.Kumar RH, Kumar MC, Thappa DM. Dapsone syndrome: a five year retrospective analysis. Indian J Lepr 1998;70:271-275.  Back to cited text no. 2    
3.Rege VL, Shukla P, Mascanrenhas MF. Dapsone syndrome in Goa. Indian J Lepr 1994;66:59-64.  Back to cited text no. 3    


Print this article  Email this article
Previous article Next article


Online since 15th March '04
Published by Wolters Kluwer - Medknow