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 ORIGINAL CONTRIBUTIONS
Year : 1999  |  Volume : 65  |  Issue : 6  |  Page : 270--272

Topical methotrexate therapy in palmoplantar psoriasis


Department of Dermatology, Kasturba Medical College, Manipal and Department of Dermatology and Venereology. Postgraduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
B C Ravi Kumar
Department of Skin & STD, Kasturba Medical College, Manipal-576 119, Karnataka
India
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Source of Support: None, Conflict of Interest: None


PMID: 20921683

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Palmoplantar psoriasis (PPP) is a disabling and disfiguring condition frequently resistant to conventional topical therapies. Sixteen patients of palmar and/or plantar psoriasis were treated with 1% methotrexate gel using propylene glycol as vehicle twice daily for 8 weeks. Patients were assessed for severity of erythema, scaling, induration and fissuring (ESIF) of the lesions weekly for one month and subsequently once every two weeks. Patients with more than 50% Improvement of the lesions were considered to have good improvement. Fifteen patients completed the study period. Eight out of ten (80%) patients with palmar psoriasis and 9 out of 14 (64%) patients with plantar psoriasis showed good improvement. The mean duration for >50% improvement was 40.3 days for palms and 52.9 days for soles. There were no side effects in any patient. Topical methotrexate, when administered in a suitable vehicle and applied for sufficient time is beneficial in PPP.






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Online since 15th March '04
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