IADVL
Indexed with PubMed and Science Citation Index (E) 
 
Users online: 142 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  Navigate here 
  Search
 
   Next article
   Previous article 
   Table of Contents
  
 Resource links
   Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   [PDF Not available] *
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

 
  In this article
   Abstract
   Introduction
   Case I
   Case 2
   Discussion
   References
   Article Figures

 Article Access Statistics
    Viewed2582    
    Printed28    
    Emailed0    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal

 


 
CASE REPORT
Year : 1998  |  Volume : 64  |  Issue : 6  |  Page : 307-308

Monomorphic cutaneous metastases with different primaries


,

Correspondence Address:
R Muthukumaran


Login to access the Email id


PMID: 20921808

Get Permissions

  Abstract 

Telangiectatic type of secondary cutaneous metastases is described with primary malignancies in different organs in a female and in a male. The clinical and histopathological features of the secondary metastases are described along with the features of the primaries manifesting as adenocarcinoma of breast in the former and squamous cell carcinoma in the larynx in the latter.


Keywords: Telangiectatic secondaries, Carcinoma breast, Carcinoma larynx


How to cite this article:
Muthukumaran R, Nirmaladevi G, Janaki V R, Sentamil. Monomorphic cutaneous metastases with different primaries. Indian J Dermatol Venereol Leprol 1998;64:307-8

How to cite this URL:
Muthukumaran R, Nirmaladevi G, Janaki V R, Sentamil. Monomorphic cutaneous metastases with different primaries. Indian J Dermatol Venereol Leprol [serial online] 1998 [cited 2014 Oct 21];64:307-8. Available from: http://www.ijdvl.com/text.asp?1998/64/6/307/4737



  Introduction Top


The primary carcinomas in certain organs like the breast, liver, stomach, large instestine, kidney, prostate, uterus and ovary are observed to produce metastasis in the skin.[1] Secondary metastasis encountered on the skin might give a clue to the primary neoplasm, but it may not be possible to recognise the primary with cutaneous secondaries like telangiectatic type and this type of deposits has been described here in connection with primaries at different sites with to tally different types of histological features.


  Case I Top


A 38-year-old cachetic woman presented with redness and thickening of the skin over the chest since 3 months. Systemic examination was normal. Dermatological examination revealed well dermacted brawny edema, erythema and induration of the skin with erythematous papules and vesicles over the presternal region and anterior chest wall. Both the breasts were hard and fixed to the underlying structures. Retraction of the nipples were observed. Axillary lymph nodes were enlarged, hard and deeply fixed bilaterally.

Hematological and biochemical investigations were normal. Skiagram of chest ultrasonogram of abdomen were also normal. Fine needle aspiration cytology (FNAC) of lymphnodes revealed polygonal cells with hyperchromatic nuclei embedded in a fibrocollagenous stroma. Mammogram showed the breast tissue adherent to the underlying bones with evident retraction of the nipples. Histopathology of the section from breast tissue revealed invasive ductal adenocarcinoma, while skin biopsy showed tumour cells in the upper dermis within the lymphatics and blood vessels. This patient was referred to radiotherapy unit for further management.


  Case 2 Top


A 69-year-old man presented with dysphagia and hoarseness of voice, raised skin lesions over right side of neck and thickening and redness of the skin of upper chest since 2 months. Systemic examination was normal

Examination revealed erythematous papules and plaques over the right side of neck. Erythema, brawny edema and induration were present over periorbital region, right ear and extended down upto right nipple [Figure - 1]. Cervical and axillary lymphnodes were hard and fixed. A mass was observed in the larynx with indirect laryngoscopy. All other systems were clinically normal.

Haematological and biochemical investigations were normal. Biopsy of the laryngeal mass revealed squamous cell carcinoma. Skin biopsy showed large vascular spaces lined by endothelial cells packed with malignant cells with hyperchromatic nuclei [Figure - 2]. This patient was also subjected to radiotherapy and was last to follow up.


  Discussion Top


Cutaneous secondaries are rare and their presence indicates poor prognosis and the patient may succumb within very short period of time. Out of the 4 types of secondaries reported in carcinoma breast telangiectatic type is rare.[2] These telangiectatic secondaries in association with squamous cell carcinoma of the larynx are still a rarity and has not been report so far. The academic interest in these cases are the similar type of cutaneous secondaries with malignant neoplasms in different organs ie. adenocarcinoma in breast and squamous cell carcinoma in larynx.

 
  References Top

1.Murie J. Skin and burns. In: Bailey and Love's Short Practice of Surgery, Ed. 22; Mann C V, Russell RCG, William N S, ELBS with Chapman and Hall, Spain, 1996;124-148.  Back to cited text no. 1    
2.Johnson W C. Metastatic carcinoma of the skin: Incidence and dissemination. In: Lever's Histopathology of the Skin, Ed. 8, Elder D, Elenitsas R, Jaworsky C, et al. Lippin Cott-Raven, Philadelphia, 1997;1011-1018.  Back to cited text no. 2    


    Figures

[Figure - 1], [Figure - 2]



 

Top
Print this article  Email this article
Previous article Next article

    

Online since 15th March '04
Published by Medknow