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Year : 1998  |  Volume : 64  |  Issue : 4  |  Page : 206-207

Effect of parenteral vitamin D3 in skin diseases

Correspondence Address:
Nusrat Banka

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Source of Support: None, Conflict of Interest: None

PMID: 20921767

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How to cite this article:
Banka N. Effect of parenteral vitamin D3 in skin diseases. Indian J Dermatol Venereol Leprol 1998;64:206-7

How to cite this URL:
Banka N. Effect of parenteral vitamin D3 in skin diseases. Indian J Dermatol Venereol Leprol [serial online] 1998 [cited 2020 May 28];64:206-7. Available from: http://www.ijdvl.com/text.asp?1998/64/4/206/4697

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Taking the clue from the topical use of vitamin D3 derivatives in psoriasis and its efficacy, we in AIMS, B.G. Nagar, tried vitamin D3 parenterally in psoriasis. For the experimentation we used Arachitol of Duphor company, 3 lakhs international units intramuscularly every week for 4 weeks and we found substantial improvement in 4 patients. In first week itself, there was decrease of erythema and scaling. By the end of 4 weeks erythema disappeared, the plaque thickness diminished by 80%, no new lesions appeared and some lesions disappeared altogether. What is of interest is that all four patients had extensive psoriasis, involving around 40% of skin surface and not few plaques.

Extending this interesting observation further, we tried the same dose in 2 cases of lichen planus. After 2 weeks, the lesions regressed by 50%. Some lesions disappeared and new ones did not appear. Both the patients had complete relief from itching.

We tried the same regimen in 4 cases of photodermatitis. After 4 weeks the lesions in all disappeared leaving residual pigmentation. All had complete freedom from itching.

The conclusion therefore is that vitamin D3, parenterally has got antipruritic, anti-inflammatory and healing properties, on skin. It is also evident that vitamin D3 administered intramuscularly could be a good adjuvant to existing dermatological therapies.

The only theoretical objection for using vitamin D3, parenterally, could be hypercalcemia. However even after repeated checking in these patients serum clcium levels did not cross 11 mg%.

We are reporting this observation, because we feel that parenteral vitamin D3 may prove an important medicine or an adjuvant in the treatment of many skin conditions.


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