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LETTERS TO THE EDITOR
Year : 1998  |  Volume : 64  |  Issue : 3  |  Page : 156

Kyrle’s disease and vitamin d resistant rickets in chronic renal failure


Department of Skin and V.D, Babu Nagar, General Hospital (ESIS), Ahmedabad-380024, India

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PMID: 20921750

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How to cite this article:
Shah S, Dave J N, Vora N S, Cardoso B, Goel R. Kyrle’s disease and vitamin d resistant rickets in chronic renal failure. Indian J Dermatol Venereol Leprol 1998;64:156

How to cite this URL:
Shah S, Dave J N, Vora N S, Cardoso B, Goel R. Kyrle’s disease and vitamin d resistant rickets in chronic renal failure. Indian J Dermatol Venereol Leprol [serial online] 1998 [cited 2020 Jun 2];64:156. Available from: http://www.ijdvl.com/text.asp?1998/64/3/156/4678



  To the Editor: Top


Kyrle's disease is one of the perforating dermatoses and a rare chronic disorder of unknown aetiology. The pathogenic event in this condition is a disorder of epidermal keratinization. Clinically Kyrle's disease is characterized by hyperkeratotic para-follicular or follicular papules, with central cone shaped plug which can be removed easily, usually involving the extensor surface of extremities. Histopathology reveals a heavy keratotic, partly parakeratotic plug containing basophilic debris lying in an invagination of the epidermis.1 Serveral authors have reported the association of Kyrle's disease with diabetes mellitus, renal failure, hyperlipidaemia, liver diseases, congestive cardiac failure with an infective process and with abnormal vitamin A metabolism.2

A 16-year-old male patient presented with asymptomatic hyperkeratotic parafoilicular and follicular discrete papules with cone shaped removable central plug since four months. The lesions first appeared on the extensor aspect of thighs and upper extremities and gradually involved the buttocks, back and lower abdomen. The patient had abnormal presence of posterior urethral valves leading to bilateral hydronephrosis and chronic renal failure since the age of seven years. His blood urea and serum creatinine were raised throughout in all repeated investigations. Later on he developed vitamin D resistant rickets. His serum calcium was 7.26 mg% and serum phosphorus was 5.3 mg%. There was no family history of similar illness. Haemogram, blood sugar, liver function test, serum lipid profile, X-ray chest and ECG were within normal limits. X-rays of skeletal system showed characteristic changes of rickets. Histopathology of skin lesions was suggestive of Kyrle's disease.

So in this patient of chronic renal failure there was a simultaneous association of vitamin D resistant rickets and Kyrle's disease.




 

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