IADVL
Indexed with PubMed and Science Citation Index (E) 
 
Users online: 1327 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  Navigate here 
  Search
 
   Next article
   Previous article 
   Table of Contents
  
 Resource links
   Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   [PDF Not available] *
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

 
  In this article
   References

 Article Access Statistics
    Viewed1403    
    Printed22    
    Emailed1    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal

 


 
LETTER TO EDITOR
Year : 1997  |  Volume : 63  |  Issue : 3  |  Page : 211

Evaluation of efficacy of therapy for psoriasis : methodological issues


Varanasi, India

Correspondence Address:
Sanjay Singh
Varanasi
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 20944330

Rights and PermissionsRights and Permissions



How to cite this article:
Singh S, Pandey S S. Evaluation of efficacy of therapy for psoriasis : methodological issues. Indian J Dermatol Venereol Leprol 1997;63:211

How to cite this URL:
Singh S, Pandey S S. Evaluation of efficacy of therapy for psoriasis : methodological issues. Indian J Dermatol Venereol Leprol [serial online] 1997 [cited 2019 Dec 6];63:211. Available from: http://www.ijdvl.com/text.asp?1997/63/3/211/22754


To the Editor

We read with interest the recent article on the efficacy of sulfasalazine versus methotrexate in the treatment of psoriasis.[1] The authors have concluded that the efficacy of sulfasalazine was comparable to methotrexate, and established drug for treating severe psoriasis. However, a few methodological issues relating to the study need to be addressed.

In each treatment group 15 patients were included. This number does not appear to be adequate for evaluation of antipsoriatic property of a medication.[2] Inadequate number of patients are likely to show no difference between two treatments when a real difference exists. Further, the assessment of efficacy was made by grading erythema, scaling, and thickness of the lesions without taking into account different regions of the body and their extent of involvement. It would have been more appropriate if an accepted method of grading psoriasis, e.g. Psoriasis Area and Severity Index,[3] was used to enable us to arrive at meaningful conclusions. Further more, the patients in the methotrexate group received 7.5 mg of the drug per week. As the antipsoriatic dose of methotrexate is 0.2 to 0.4 mg per kg body weight per weak,[4] it appears that the patients received a suboptimal dose. It is highly likely that with an optimum dose the response would have been much better with methotrexate.

Though the authors have provided interesting preliminary findings, in view of the foregoing discussion, it appears that the achievement of the objective of the study[1] would require further work.

 
  References Top

1.Bharti R Girgla PS. Sulfasalazine in treatment of psoriasis, Ind J Dermatol Venereol Leprol 1996;62:87-88.  Back to cited text no. 1      
2.Singh S, Gopal J, Mishra RN, et al. Topical 0.05% betamethasone dipropionate: efficacy in psoriasis with once a day versus twice a day application, Br J Dermatol 1995;133:497-498.  Back to cited text no. 2      
3.Fredriksson T, Pettersson U. Severe psoriasis : oral therapy with a new retinoid, Dermatologica 1978;157:238-244.  Back to cited text no. 3      
4.Baker H. Psoriasis, In : Textbook of Dermatology Edited by Rook A, Wilkinson DS, Ebling FJG, et al, Blackwell, Oxford, 1986:1469-1532.  Back to cited text no. 4      




 

Top
Print this article  Email this article
Previous article Next article

    

Online since 15th March '04
Published by Wolters Kluwer - Medknow