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STUDIES
Year : 1997  |  Volume : 63  |  Issue : 2  |  Page : 89-90

Bacterial culture and sensitivity in pemphigus



Correspondence Address:
Ja


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Source of Support: None, Conflict of Interest: None


PMID: 20944282

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  Abstract 

Infection is the commonest cause of death in pemphigus and the commonest infection is Staphylococcus aureus bacteremia. In present study bacterial culture and sensitivity from the lesion was done in 25 patients of pemphigus vulgaris and accordingly antibiotics were given along with other treatment of pemphigus i.e. steroid, immunosuppressive drug etc. Most common pathogenic bacteria isolated was Staphylococcus aureus and it was sensitive to cloxacillin, erythromycin, cefotaxime and lincomycin.


Keywords: Bacterial infection, Culture and sensitivity, Pemphigus


How to cite this article:
Ja. Bacterial culture and sensitivity in pemphigus. Indian J Dermatol Venereol Leprol 1997;63:89-90

How to cite this URL:
Ja. Bacterial culture and sensitivity in pemphigus. Indian J Dermatol Venereol Leprol [serial online] 1997 [cited 2019 Sep 16];63:89-90. Available from: http://www.ijdvl.com/text.asp?1997/63/2/89/4525



  Introduction Top


Pemphigus is an autoimmune intraepidermal blistering disease of the skin and mucous membrane.[2][3] The term is derived from Greek word pemphix for blister or bubble.[4] Before the advent of corticosteroids and antibiotic therapy pemphigus vulgaris caused a substantial mortality. Steroids, immunosuppressive agents and antibiotics have drastically improved the prognosis.

The most common causes of death in pemphigus are septicemia and pulmonary embolism; the former usually follows cutaneous Staphylococcus aureus Scientific Name Search  infections.[1][5] The purpose of this study was to find out the common pathogenic bacteria causing secondary infection in pemphigus by culture and sensitivity study.


  Materials and Methods Top


This study was conducted from November 1993 to July 1995 and comprised of 25 patients of pemphigus vulgaris. Detailed history and all clinical findings were recorded. All routine investigations were done. Diagnosis was confirmed by Tzank test and skin biopsy. Bacterial culture, gram staining and antibiotic sensitivity test was done in every patient and depending upon the report antibiotic was given in order of preference along with other treatment of pemphigus.


  Results Top


Staphylococcus aureus coagulase positive organism was isolated from the lesions in 18 patients. Beta haemolytic streptococci,  Pseudomonas aeruginosa Scientific Name Search d  Escherichia More Details coli were isolated in 3 patients.

Staphylococcus aureus showed maximum sensitivity to cloxacillin, erythromycin, cefotaxime and lincomycin. It also showed sensitivity to gentamicin, ampicillin, cephalexin and quinolones.

Pseudomonas aeruginosa was very sensitive to ciprofloxacin and sensitive to gentamicin, cefotaxime, norfloxacin, amikacin, ceftazidine and pefloxacin.

Escherichia coli was very sensitive to amikacin and netilmicin. Beta haemolytic streptococci showed sensitivity to cephaloridine, gentamicin, amikacin, cloxacillin, lincomycin, cefotaxime and quinolones.


  Discussion Top


The combined use of corticosteroids, adjuvant therapy and antibiotics according to culture and sensitivity report has shown promising results. Thus it may contribute to some extent to decline mortality rate due to septicaemia which usually follows secondary infection of the cutaneous lesions.

 
  References Top

1.Ahmed AR, Moy R. Death in pemphigus. J Am Acad Dermatol 1982;7:221-8.  Back to cited text no. 1  [PUBMED]  
2.Korman NJ. Pemphigus. J Am Acad Dermatol 1988;18:1219-38.  Back to cited text no. 2    
3.Korman NJ. Pemphigus. Dermatologic Clinics 1990;8:689-700.  Back to cited text no. 3  [PUBMED]  
4.Lever WF. Pemphigus. Medicine 1953;32:1-123.  Back to cited text no. 4  [PUBMED]  
5.Savin JA. The events leading to the death of patients with pemphigus and pemphigoid. Br J Dermatol 1979;101:521.  Back to cited text no. 5  [PUBMED]  


    Tables

[Table - 1], [Table - 2]



 

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