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Year : 1997  |  Volume : 63  |  Issue : 1  |  Page : 71-72

Cetirizine induced urticaria

Jaipur, India

Correspondence Address:
Puneet Bhargava
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Source of Support: None, Conflict of Interest: None

PMID: 20944276

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How to cite this article:
Bhargava P, Bhargava S, Kuldeep C M, Mathur N K. Cetirizine induced urticaria. Indian J Dermatol Venereol Leprol 1997;63:71-2

How to cite this URL:
Bhargava P, Bhargava S, Kuldeep C M, Mathur N K. Cetirizine induced urticaria. Indian J Dermatol Venereol Leprol [serial online] 1997 [cited 2020 Aug 9];63:71-2. Available from:

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Cetirizine in the carboxylic acid metabolite of hydroxyzine used commonly in the treatment of acute and recurrent episodes of urticaria.[1] Use of this drug causes a decrease in immediate release of histamine, in the detection of platelet activation factor, in the influx of eosinophils and prostaglandin D2 generation.[2] Side effects include headache, dizziness, drowsiness, agitation, dry mouth and gastrointestinal discomfort. Recently a 25-year-old Hindu female presented to us with contact dermatitis involving the hands. She was prescribed cetirizine 10 mg HS along with topical corticosteroid ointment. She took this medication for 2 days and came back on third day with generalised urticarial reaction. The lesions appeaed within half an hour of the intake of third dose of cetirizine.

A complete physical examination and laboratory investigations were done to exclude other cases of urticaria. Cetirizine was stopped and the patient was treated with dexchlorpheniramine maleate 2 mg twice daily with subsidence of lesions within 3 days.

Rechallenge with tablet of cetirizine produced pruritus and urticarial wheels. To our knowledge, urticaria occurring after cetirizine use has not been described in literature although it has been mentioned as a rare complication after use of terfenadine,[2] which also is an antihistaminic drug. This case report is interesting because here an antihistaminic drug is causing urticaria for which it is used as a therapeutic modality.

  References Top

1.Wood SG, et al. Metabolism and pharmacokinetics of 14C- cetirizine in humans. Ann Allergy 1987;59 (Suppl):31.  Back to cited text no. 1      
2.Soter NA. Antihistamines In:Fitzpatrick TB, Eisen AZ, Wolff K, et al, editors. Dermatology in general medicine. New yark: McGraw Hill Inc, 1993:2909-16.  Back to cited text no. 2      


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