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Year : 1997  |  Volume : 63  |  Issue : 1  |  Page : 5--8

Lack of antinuclear antibody in children with atopic dermatitis


1 Departments of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
2 Departments of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Sandipan Dhar
H No 1-N-14, Vigyan Nagar, Kota-324005
India
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Source of Support: None, Conflict of Interest: None


PMID: 20944247

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Antinuclear antibody (ANA) was assayed in 76 children with atopic dermatitis (AD) of which 46 were males and 30 females. Their ages ranged from 6 months to 12 years (mean 3.4 years). Age at onset of AD ranged from 2 months to 5.5 years (mean 1.9 years) and its duration ranged from 4 months to 4 years (mean 1.2 years). While facial lesions were present in 56 (73.3%) patients, 49 (64.5%) patients had predominant involvement of extensors. As per severity score designed by Rajka and Langerland, 31 (40.8%), 42 (55.3%) and 3 (3.9%) patients had mild, moderate and severe diseases respectively. History of photosensitivity was present in 6 (7.9%) patients. Serum samples were positive for ANA in a very low titre (1:20) in 2/6 patients with facial lesions. However LE cell, rheumatoid factor and C-reactive proteins were negative and serum complement levels were within normal limits.






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