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LETTER TO EDITOR
Year : 1996  |  Volume : 62  |  Issue : 3  |  Page : 203-204

Paucity of immune complexes in skin lesions of lichen planus




Correspondence Address:
C R Srinivas


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Source of Support: None, Conflict of Interest: None


PMID: 20948052

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How to cite this article:
Srinivas C R, Alfred S. Paucity of immune complexes in skin lesions of lichen planus. Indian J Dermatol Venereol Leprol 1996;62:203-4

How to cite this URL:
Srinivas C R, Alfred S. Paucity of immune complexes in skin lesions of lichen planus. Indian J Dermatol Venereol Leprol [serial online] 1996 [cited 2019 Dec 7];62:203-4. Available from: http://www.ijdvl.com/text.asp?1996/62/3/203/4388



  To the Editor, Top


This is with reference to the article entitled "Paucity of immune complexes in skin lesions of lichen planus"[1] published recently in the Journal. We wish to share our experience on direct immunofluorescence (IMF) in lichen planus(LP). As reported by the authors we have also observed colloid bodies showing IgM, IgA, IgG and C3 deposits, however, in addition to the above we have consistently observed a ragged fibrin band deposit along the dermoepidermal junction. The consistent presence of fibrin has been reported by other authors.[2],[3] In addition, the authors have correlated the presence of positive IMF staining of colloid bodies with the age of the lesion. Although we have not correlated the presence of colloid bodies with the age of the lesion, we have detected its presence in almost all cases, except in the oral mucosa. Paucity of colloids in the oral mucosa has been reported.[4] To conclude, we feel that the presence of fibrin band should be looked for in LP.



 
  References Top

1.Dhar S, Kanwar JA, Dawn G, Sehgal S. Paucity of immune complexes in skin lesions of lichen planus. Ind J Dermatol Venereol Leprol 1995;61:21-5.  Back to cited text no. 1    
2.Ueki H, Yaoita H. A color atlas of dermatoimmunohistocytology, 1989.  Back to cited text no. 2    
3.Abell E, Presburg DG, Marks R, et al. The diagnostic significance of immunoglobulin and fibrin deposition in lichen planus. Br J Dermatol 1975;93:17.  Back to cited text no. 3    
4.Ongley RC. Immunofluorescent microscopy in dermatology: diagnostic applications. Int J Dermatol 1982;21:233-40.  Back to cited text no. 4  [PUBMED]  




 

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