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Year : 1996  |  Volume : 62  |  Issue : 2  |  Page : 87--88

Sulfasalazine in treatment of psoriasis

Department of Skin and STD, Sri Guru Ram Das Hospital, Amritsar-143001, India

Correspondence Address:
Rakesh Bharti
424, Basant Avenue, Amritsar-143001
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Source of Support: None, Conflict of Interest: None

PMID: 20947988

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A 5-lipoxygenase inhibitor-sulfasalazine was compared to a known effective drug-methotrexate in psoriasis. Fifteen patients each were put on sulfasalazine (1500 mg/day) and methotrexate (7.5 mg/week). Assessment was made on the basis of EST (Erythema, Scaling and Thickness) scale, initially and then weekly upto 4 weeks followed by 4 weekly upto 12 weeks. Efficacy was comparable for the 2 drugs: decrease in mean EST in patients on methotrexate and sulfasalazine therapy was 86.55% and 83.64% at 4 weeks; and 92.86% and 92.13% at 12 weeks respectively. Nine patients on sulfasalazine therapy and 10 patients on methotrexate therapy had complete clearance at the end of 12 weeks.


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Online since 15th March '04
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