IADVL
Indexed with PubMed and Science Citation Index (E) 
 
Users online: 874 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  Navigate here 
  Search
 
   Next article
   Previous article 
   Table of Contents
  
 Resource links
   Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   [PDF Not available] *
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

 
  In this article
   To the Editor,
   References

 Article Access Statistics
    Viewed2377    
    Printed34    
    Emailed0    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal

 


 
LETTER TO EDITOR
Year : 1996  |  Volume : 62  |  Issue : 2  |  Page : 131-132

Clearance of plaque psoriasis following irritation due to calcipotriol




Correspondence Address:
Gurcharan Singh


Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 20948011

Rights and PermissionsRights and Permissions



How to cite this article:
Singh G, Sangolli P, Dash K, Grove. Clearance of plaque psoriasis following irritation due to calcipotriol. Indian J Dermatol Venereol Leprol 1996;62:131-2

How to cite this URL:
Singh G, Sangolli P, Dash K, Grove. Clearance of plaque psoriasis following irritation due to calcipotriol. Indian J Dermatol Venereol Leprol [serial online] 1996 [cited 2019 Jun 19];62:131-2. Available from: http://www.ijdvl.com/text.asp?1996/62/2/131/4348



  To the Editor, Top


A 9-year-old girl presented with extensive plaque psoriasis of 3 months duration. In view of inadequate response to topical coal tar and steroid therapy, calcipotriol (50 μg/g) was started. Patient developed irritant reaction to topical medicament within a week of commencement of therapy, manifesting as severe burning sensation locally associated with aggravation of lesional and perilesional erythema. Calcipotriol was discontinued for the fear of precipitating exfoliative dermatitis and patient was put on topical emollients. Surprisingly review after two weeks revealed complete regression of skin lesions with postinflammatory hyperpigmentation.

In clinical studies calcipotriol has been shown to be an effective and well tolerated treatment for psoriasis.[1] Lesional and perilesional irritation is the most common adverse effect reported with the drugs.[2] Clearance of lesions following irritant reaction could be attributed to increased tissue concentration of drug subsequent to enhanced blood supply following inflammation or reverse Koebner phenomenon in this case.

 
  References Top

1.Kragballe K. Treatment of psoriasis with calcipotriol and other vitamin D analogues. J Am Acad Dermatol 1992;27:1001-8.  Back to cited text no. 1  [PUBMED]  
2.Kragballe K, Gjertsen BT, Hoop D, et al. Double-blind, right/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris. Lancet 1991;337:193-5.  Back to cited text no. 2  [PUBMED]  




 

Top
Print this article  Email this article
Previous article Next article

    

Online since 15th March '04
Published by Wolters Kluwer - Medknow