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Year : 1996  |  Volume : 62  |  Issue : 2  |  Page : 131-132

Clearance of plaque psoriasis following irritation due to calcipotriol

Correspondence Address:
Gurcharan Singh

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Source of Support: None, Conflict of Interest: None

PMID: 20948011

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How to cite this article:
Singh G, Sangolli P, Dash K, Grove. Clearance of plaque psoriasis following irritation due to calcipotriol. Indian J Dermatol Venereol Leprol 1996;62:131-2

How to cite this URL:
Singh G, Sangolli P, Dash K, Grove. Clearance of plaque psoriasis following irritation due to calcipotriol. Indian J Dermatol Venereol Leprol [serial online] 1996 [cited 2020 Jan 23];62:131-2. Available from: http://www.ijdvl.com/text.asp?1996/62/2/131/4348

  To the Editor, Top

A 9-year-old girl presented with extensive plaque psoriasis of 3 months duration. In view of inadequate response to topical coal tar and steroid therapy, calcipotriol (50 μg/g) was started. Patient developed irritant reaction to topical medicament within a week of commencement of therapy, manifesting as severe burning sensation locally associated with aggravation of lesional and perilesional erythema. Calcipotriol was discontinued for the fear of precipitating exfoliative dermatitis and patient was put on topical emollients. Surprisingly review after two weeks revealed complete regression of skin lesions with postinflammatory hyperpigmentation.

In clinical studies calcipotriol has been shown to be an effective and well tolerated treatment for psoriasis.[1] Lesional and perilesional irritation is the most common adverse effect reported with the drugs.[2] Clearance of lesions following irritant reaction could be attributed to increased tissue concentration of drug subsequent to enhanced blood supply following inflammation or reverse Koebner phenomenon in this case.

  References Top

1.Kragballe K. Treatment of psoriasis with calcipotriol and other vitamin D analogues. J Am Acad Dermatol 1992;27:1001-8.  Back to cited text no. 1  [PUBMED]  
2.Kragballe K, Gjertsen BT, Hoop D, et al. Double-blind, right/left comparison of calcipotriol and betamethasone valerate in treatment of psoriasis vulgaris. Lancet 1991;337:193-5.  Back to cited text no. 2  [PUBMED]  


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