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| LETTER TO EDITOR |
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| Year : 1996 | Volume
: 62
| Issue : 2 | Page : 128-129 |
Tropical triamcinolone acetonide in an indigenous orabase in oral lichen planus
Vijay Gandhi, RK Pandhi
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Correspondence Address:
Vijay Gandhi
PMID: 20948007
How to cite this article:
Gandhi V, Pandhi R K. Tropical triamcinolone acetonide in an indigenous orabase in oral lichen planus. Indian J Dermatol Venereol Leprol 1996;62:128-9 |
How to cite this URL:
Gandhi V, Pandhi R K. Tropical triamcinolone acetonide in an indigenous orabase in oral lichen planus. Indian J Dermatol Venereol Leprol [serial online] 1996 [cited 2013 May 25];62:128-9. Available from: http://www.ijdvl.com/text.asp?1996/62/2/128/4345 |
| To the Editor, | |  |
Oral lichen planus (LP) affects upto 1% of the population.[1] It is about eight times more common than cutaneous LP.[1] The treatment of oral LP is a therapeutic problem. Topical steroids in a conventional cream base do not adhere to the oral mucosa for a sufficiently long time to cause therapeutic action. Use of intralesional corticosteroids, though effective, has the drawback of pain at injection sites and risk of secondary infection. Other therapeutic modalities include oral vitamin A,[2] topical cyclosporine (100 mg/ ml) in the form of an oral rinse[3] and temarotene,[4] a new oral retinoid. Orabase[5] (a gel of carboxymethylcellulose, pectin and gelatin), available commercially in the West, is an ideal vehicle for topical corticosteroids for oral mucosa. We have developed an indigenous orabase and used it as a vehicle for triamcinolone acetonide (40 mg/ml). This was prepared by adding Vi syneral syrup (30 ml) and Moisol (hydroxypropyl cellulose) eye drops (10 ml). Triamcinolone acetonide (40 mg/ml) was added in this base. The preparation adheres to the oral mucosa for a long time and can be applied twice daily.
We treated 20 patients with oral LP of varying severity with this preparation applied topically twice a day. A remarkable improvement in 16 (80%) patients was noticed after 4 weeks of use. Ten out of 20 (50%) patients showed complete clearance after 3 to 4 months. They are on regular follow up to detect any signs of recurrence. No side effects have been noticed. We propose topical triamcinolone acetonide in indigenous orabase as the treatment of choice due to its cost effectiveness, safety and excellent therapeutic efficacy.
| References | | |
| 1. | Scully C. The oral cavity. In : Champion RH, Burton JL, Ebling FJG, eds. Textbook of dermatology. 5th edn. London : Blackwell Scientific Publications, 1991:2721-3.  |
| 2. | Scully C. Treatment of oral lichen planus. Lancet 1990;336:913-4. |
| 3. | Eisen D, Ellis CN, Duell EA, et al. Effects of topical cyclosporine rinse on oral lichen planus. N Engl J Med 1990;323:290-4. [PUBMED] |
| 4. | Bollay W. Treatment of lichen planus with temarotene. Lancet 1989;ii:974. |
| 5. | Wilkinson JD. Formulary of topical applications. In : Champion RH, Burton JL, Ebling FJG, eds. Textbook of dermatology. London : Blackwell Scientific Publications, 1991:3121-8. |
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