IADVL
Indexed with PubMed and Science Citation Index (E) 
 
Users online: 4124 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  Navigate here 
  Search
 
   Next article
   Previous article 
   Table of Contents
  
 Resource links
   Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   [PDF Not available] *
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

 
  In this article
   To the Editor,
   References

 Article Access Statistics
    Viewed4258    
    Printed56    
    Emailed1    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal

 


 
LETTER TO EDITOR
Year : 1996  |  Volume : 62  |  Issue : 2  |  Page : 128-129

Tropical triamcinolone acetonide in an indigenous orabase in oral lichen planus




Correspondence Address:
Vijay Gandhi


Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 20948007

Rights and PermissionsRights and Permissions



How to cite this article:
Gandhi V, Pandhi R K. Tropical triamcinolone acetonide in an indigenous orabase in oral lichen planus. Indian J Dermatol Venereol Leprol 1996;62:128-9

How to cite this URL:
Gandhi V, Pandhi R K. Tropical triamcinolone acetonide in an indigenous orabase in oral lichen planus. Indian J Dermatol Venereol Leprol [serial online] 1996 [cited 2019 Jun 19];62:128-9. Available from: http://www.ijdvl.com/text.asp?1996/62/2/128/4345



  To the Editor, Top


Oral lichen planus (LP) affects upto 1% of the population.[1] It is about eight times more common than cutaneous LP.[1] The treatment of oral LP is a therapeutic problem. Topical steroids in a conventional cream base do not adhere to the oral mucosa for a sufficiently long time to cause therapeutic action. Use of intralesional corticosteroids, though effective, has the drawback of pain at injection sites and risk of secondary infection. Other therapeutic modalities include oral vitamin A,[2] topical cyclosporine (100 mg/ ml) in the form of an oral rinse[3] and temarotene,[4] a new oral retinoid. Orabase[5] (a gel of carboxymethylcellulose, pectin and gelatin), available commercially in the West, is an ideal vehicle for topical corticosteroids for oral mucosa. We have developed an indigenous orabase and used it as a vehicle for triamcinolone acetonide (40 mg/ml). This was prepared by adding Vi syneral syrup (30 ml) and Moisol (hydroxypropyl cellulose) eye drops (10 ml). Triamcinolone acetonide (40 mg/ml) was added in this base. The preparation adheres to the oral mucosa for a long time and can be applied twice daily.

We treated 20 patients with oral LP of varying severity with this preparation applied topically twice a day. A remarkable improvement in 16 (80%) patients was noticed after 4 weeks of use. Ten out of 20 (50%) patients showed complete clearance after 3 to 4 months. They are on regular follow up to detect any signs of recurrence. No side effects have been noticed. We propose topical triamcinolone acetonide in indigenous orabase as the treatment of choice due to its cost effectiveness, safety and excellent therapeutic efficacy.



 
  References Top

1.Scully C. The oral cavity. In : Champion RH, Burton JL, Ebling FJG, eds. Textbook of dermatology. 5th edn. London : Blackwell Scientific Publications, 1991:2721-3.  Back to cited text no. 1    
2.Scully C. Treatment of oral lichen planus. Lancet 1990;336:913-4.  Back to cited text no. 2    
3.Eisen D, Ellis CN, Duell EA, et al. Effects of topical cyclosporine rinse on oral lichen planus. N Engl J Med 1990;323:290-4.  Back to cited text no. 3  [PUBMED]  
4.Bollay W. Treatment of lichen planus with temarotene. Lancet 1989;ii:974.  Back to cited text no. 4    
5.Wilkinson JD. Formulary of topical applications. In : Champion RH, Burton JL, Ebling FJG, eds. Textbook of dermatology. London : Blackwell Scientific Publications, 1991:3121-8.  Back to cited text no. 5    




 

Top
Print this article  Email this article
Previous article Next article

    

Online since 15th March '04
Published by Wolters Kluwer - Medknow