IADVL
Indexed with PubMed and Science Citation Index (E) 
 
Users online: 2570 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  Navigate here 
  Search
 
   Next article
   Previous article 
   Table of Contents
  
 Resource links
   Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   [PDF Not available] *
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

 
  In this article
   Abstract
   Introduction
   Case Reports
   Discussion
   References

 Article Access Statistics
    Viewed6781    
    Printed50    
    Emailed1    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal

 


 
CASE REPORT
Year : 1996  |  Volume : 62  |  Issue : 2  |  Page : 114-115

Continual skin peeling syndrome




Correspondence Address:
K Deepak Mathur


Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 20947998

Rights and PermissionsRights and Permissions

  Abstract 

Two cases of continual skin peeling syndrome (CSPS) are presented


Keywords: Continual skin peeling syndrome


How to cite this article:
Mathur K D, Bhargava P, Singh P, Ag. Continual skin peeling syndrome. Indian J Dermatol Venereol Leprol 1996;62:114-5

How to cite this URL:
Mathur K D, Bhargava P, Singh P, Ag. Continual skin peeling syndrome. Indian J Dermatol Venereol Leprol [serial online] 1996 [cited 2019 Jun 26];62:114-5. Available from: http://www.ijdvl.com/text.asp?1996/62/2/114/4336



  Introduction Top


Continual skin peeling syndrome (CSPS) is a rare autosomal recessive disorder characterised by asymptomatic, generalized, non-inflammatory exfoliation of the stratum corneum.[1] Different nomenclatures have been used in the literature, namely keratolysis exfoliativa congenita,[2] deciduous skin,[3] familial continual skin peeling,[4] peeling skin syndrome,[5] etc. We are reporting 2 cases of this rare entity.


  Case Reports Top


Case 1: A 55-year-old Hindu male presented with thickening and peeling of the skin over extensor aspect of both hands, feet, back of the elbow and knee since childhood. Patient reported that his skin over the above sites thickens and peels off in sheets continuously throughout the year but skin over the remaining parts of the body peels off during summers only, which is normal in winters.

No family history of any dermatosis could be elicited. Patient had used emollients, keratolytics, vitamins A and E in past with partial relief. Patient was otherwise healthy.

On cutaneous examination, bilaterally symmetric well defined hyperkeratotic plaques were present on the dorsal aspect of hands, feet, elbow and knees. Rubbing of skin with pressure on these sites induced peeling; large sheets of skin without bleeding and pain leaving behind shiny erythematous area. The skin of remaining body showed fine scaling which could be removed easily. Palms, soles, scalp, hair, teeth, eyes, nails and mucous membranes were normal. Histopathological examination revealed orthokeratotic hyperkeratosis with separation within stratum corneum. Remaining epidermis and dermis was normal.

Case 2: A 35-year-old Hindu male presented with thickened skin over the back of both hands and feet. The skin at above sites got macerated and peeled off during summer or by dipping in water leaving behind glazed erythematous area without any bleeding, oozing or pain. There was no family history of any dermatological disorder. On cutaneous examination, bilaterally symmetric hyperkeratotic plaques were present over dorsum of hands and feet. Remaining skin of body was normal. No other dermatological and systemic abnormality was present.


  Discussion Top


CSPS is a rare dermatological entity and only few cases have been reported from India.[1] The cause of this interesting disorder is not known. Kurban and Azar[4] on the basis of autoradiography suggested CSPS to be a hyperproliferative state. Silverman and Ellis[6] found that level of cleavage in CSPS is within the stratum corneum. According to them, the barrier function and cohesion got disturbed due to abnormal deposition of lipids, which leads to the desquamation of stratum corneum. The exact events and nature of lipids have to be explored.

 
  References Top

1.Gharpuray MB, Mutalik S. Skin peeling syndrome. Ind J Dermatol Venereol Leprol 1994;60:170-2.  Back to cited text no. 1    
2.Fox H. Skin sheeding (keratolysis exfoliativa congenita) : report of a case. Arch Dermatol 1921;3:202.  Back to cited text no. 2    
3.Behcet PE. Deciduous skin. Arch Dermatol 1938;37:267.  Back to cited text no. 3    
4.Kurban AK, Azar HA. Familial continual skin peeling. Br J Dermatol 1969;81:191-5.  Back to cited text no. 4  [PUBMED]  
5.Levy SB, Goldsmith LA. The peeling skin syndrome. J Am Acad Dermatol 1982;7:606-13.  Back to cited text no. 5  [PUBMED]  
6.Silverman AK, Ellis CN, et al. Continual skin peeling syndrome. Arch Dermatol 1986;122:71-5.  Back to cited text no. 6  [PUBMED]  




 

Top
Print this article  Email this article
Previous article Next article

    

Online since 15th March '04
Published by Wolters Kluwer - Medknow