|LETTER TO EDITOR
|Year : 1995 | Volume
| Issue : 6 | Page : 384-385
Atypical subcorneal pustular dermatosis
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Rajagopal R. Atypical subcorneal pustular dermatosis. Indian J Dermatol Venereol Leprol 1995;61:384-5
| To the Editor,|| |
A 43-year-old man presented with a minimally itchy diffuse erythematous maculopapular eruption on the lateral aspects of chest and abdomen, neck and proximal upper and lower limbs of two days duration. He had taken 8 tablets of furazolidone and 4 tablets of levamisole for diarrhoea two days prior to onset of the lesions. Dermatological examination revealed diffuse erythematous maculopapular eruption with ill-defined margins on afore-mentioned areas with complete sparing of axillary and groin flexures. Face and mucous membranes were not involved. Patient was comfortable except for low grade fever. At this juncture there were no pustules and, with the history, possibility of drug eruption was high. A day later discrete flaccid vesicles were seen progressing to vesico-pustules with characteristic hypopyon formation. Gram stain of pus from pustules showed large number of neutrophils and no bacteria. Histopathology was consistent with clinical diagnosis of subcorneal pustular dermatosis (SCPD) and there was dramatic improvement with dapsone.
Six of the seven patients initially described by Sneddon and Wilkinson were women and mean age of onset was 54.8 years. However younger cases have been described in India in males., The eruptions tend to coalesce and produce annular, circinate or bizarre patterns over mainly axillae, groins and sub-mammary regions, abdomen and flexor aspects of limbs.
The atypical features of the case described are (a) male sex, (b) younger age of onset, (c) sudden onset, (d) low grade fever, (e) sparing of flexures, and (f) lack of annular or circinate lesions.
| References|| |
|1.||Sneddon IB, Wilkinson DS. Subcorneal pustular dermatosis. Br J Dermatol 1956;68:385. [PUBMED] |
|2.||Singh RP. Subcorneal pustular dermatosis. Ind J Dermatol 1963;9:5. |
|3.||Gurcharan S, Malik AK, Bharadwaj M, et al. Sub-corneal pustular dermatosis. Ind J Dermatol Venereol Leprol 1995;61:67-8. |
|4.||Honigsmann H, Wolff K. Subcorneal pustular dermatosis. In: Dermatology in general medicine (Fitzpatrick TB, Eisen ZA, Wolff K, et al, eds), 4th edn. New York: McGraw-Hill, 1993;645-8. |