Indexed with PubMed and Science Citation Index (E) 
Users online: 671 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  Navigate here 
   Next article
   Previous article 
   Table of Contents
 Resource links
   Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   [PDF Not available] *
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

  In this article
   To the Editor,

 Article Access Statistics
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal


Year : 1995  |  Volume : 61  |  Issue : 6  |  Page : 383-384

Kyrle's disease

Correspondence Address:
G Kalla

Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 20953035

Rights and PermissionsRights and Permissions

How to cite this article:
Kalla G, Kachhawa D, Goyal M A, Mathur D. Kyrle's disease. Indian J Dermatol Venereol Leprol 1995;61:383-4

How to cite this URL:
Kalla G, Kachhawa D, Goyal M A, Mathur D. Kyrle's disease. Indian J Dermatol Venereol Leprol [serial online] 1995 [cited 2019 Oct 22];61:383-4. Available from: http://www.ijdvl.com/text.asp?1995/61/6/383/4288

  To the Editor, Top

Kyrle's disease is a rare disorder of keratinization, first described by Kyrle in 1916. It usually presents as multiple hyperkeratotic follicular and parafollicular papules with a central keratotic plug. The cause of disease is not known but it may be associated with diabetes, chronic renal failure and hepatic dysfunction.[1],[2] A case of Kyrle's disease is reported.

A 23-year-old man presented with slowly progressive mildly pruritic, painless, discrete polygonal, symmetrical hyperkeratotic papules of 0.5 cm to 1.0 cm size on the extensors of upper limbs, lower limbs and on buttocks. In the centre of papules a cone-shaped keratotic plug was present which was readily removed by the help of curette. Routine examination of blood, urine and stool were within normal limits. Patient was not having diabetes mellitus, renal failure or hepatic dysfunction. The clinical diagnosis of Kyrle's disease was made which was subsequently confirmed by the histopathological examination by presence of hyperkeratosis and parakeratosis of epidermis and a keratinous mass seen penetrating the follicular wall at places with dermal infiltrate of predominantly lymphocytes.

It is thought that metabolic disorders associated with Kyrle's disease are somehow responsible for development of abnormal Keratinization and connective tissue changes,[3] but the actual mechanism may be different as in our case the Kyrle's disease was seen in otherwise healthy adult male.

  References Top

1.Carter VH, Constantine VS. Kyrle's disease-I. Clinical findings in five cases and review of literature. Arch Dermatol 1968;97:624-32.  Back to cited text no. 1  [PUBMED]  
2.Constantine VS, Carter VH. Kyrle's disease-II. Histological finding in five cases and review of literature. Arch Dermatol 1968;97:633-9.  Back to cited text no. 2    
3.Patterson JW, The perforating disorders. J Am Acad Dermatol 1984;10:561-81.  Back to cited text no. 3    


Print this article  Email this article
Previous article Next article


Online since 15th March '04
Published by Wolters Kluwer - Medknow