|LETTER TO EDITOR
|Year : 1995 | Volume
| Issue : 6 | Page : 383-384
G Kalla, Dilip Kachhawa, M Archana Goyal, D Mathur
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Kalla G, Kachhawa D, Goyal M A, Mathur D. Kyrle's disease. Indian J Dermatol Venereol Leprol 1995;61:383-4
| To the Editor,|| |
Kyrle's disease is a rare disorder of keratinization, first described by Kyrle in 1916. It usually presents as multiple hyperkeratotic follicular and parafollicular papules with a central keratotic plug. The cause of disease is not known but it may be associated with diabetes, chronic renal failure and hepatic dysfunction., A case of Kyrle's disease is reported.
A 23-year-old man presented with slowly progressive mildly pruritic, painless, discrete polygonal, symmetrical hyperkeratotic papules of 0.5 cm to 1.0 cm size on the extensors of upper limbs, lower limbs and on buttocks. In the centre of papules a cone-shaped keratotic plug was present which was readily removed by the help of curette. Routine examination of blood, urine and stool were within normal limits. Patient was not having diabetes mellitus, renal failure or hepatic dysfunction. The clinical diagnosis of Kyrle's disease was made which was subsequently confirmed by the histopathological examination by presence of hyperkeratosis and parakeratosis of epidermis and a keratinous mass seen penetrating the follicular wall at places with dermal infiltrate of predominantly lymphocytes.
It is thought that metabolic disorders associated with Kyrle's disease are somehow responsible for development of abnormal Keratinization and connective tissue changes, but the actual mechanism may be different as in our case the Kyrle's disease was seen in otherwise healthy adult male.
| References|| |
|1.||Carter VH, Constantine VS. Kyrle's disease-I. Clinical findings in five cases and review of literature. Arch Dermatol 1968;97:624-32. [PUBMED] |
|2.||Constantine VS, Carter VH. Kyrle's disease-II. Histological finding in five cases and review of literature. Arch Dermatol 1968;97:633-9. |
|3.||Patterson JW, The perforating disorders. J Am Acad Dermatol 1984;10:561-81. |