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Year : 1995  |  Volume : 61  |  Issue : 5  |  Page : 323-324

Autohaemotherapy in chronic urticaria

Correspondence Address:
Adarsh Chopra

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Source of Support: None, Conflict of Interest: None

PMID: 20953006

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How to cite this article:
Chopra A, Mamta, Chopra D. Autohaemotherapy in chronic urticaria. Indian J Dermatol Venereol Leprol 1995;61:323-4

How to cite this URL:
Chopra A, Mamta, Chopra D. Autohaemotherapy in chronic urticaria. Indian J Dermatol Venereol Leprol [serial online] 1995 [cited 2020 Mar 29];61:323-4. Available from: http://www.ijdvl.com/text.asp?1995/61/5/323/4258

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Urticaria is characterised by transient erythematous or oedematous swelling of dermis or subcutaneous tissue.[1] It can be acute when it is of less than 2 months duration or it can be chronic if it lasts for more than 2 months.

Besides genetic predisposition many other factors are responsible for urticaria e.g., foods and preservatives, drugs like penicillin, salicylates etc, insect bites, emotional stress and internal diseases like anaemia, worm infestation etc. Many physical factors like heat, cold, water, sun exposure also promote urticaria like reactions. Some defects in the immune regulatory system can also lead to urticaria.

Different modalities are used for treatment of urticaria. Main line of treatment consists of treatment of the cause, if detectable, alongwith antihistaminics. But combination of both H1 and H2 blockers are helpful as they block the release of histamine at both H1 and H2 receptor sites. Corticosteroids are used in acute cases only. Mast cell stabilizing agents like sodium cromoglycate, terbutaline and ketotifen are also used. Tranquilizers are of help in cases with psychogenic component. Topically soothing agents like calamine are used. But none of these modalities has given satisfactory results. Autohaemotherapy is being evaluated for treatment in chronic urticaria.

We have tried autohaemotherapy in 50 cases of chronic urticaria. Every possible cause was ruled out in all the cases. Investigations were within normal limits except for more than 7% eosinophils in every case. 50 patients were given autohaemotherapy and 50 were treated by other modalities. The procedure consisted of taking blood from patient's cubital vein and directly injecting it into gluteus muscle of same patient without mixing the blood with any anticoagulant. During first week 2 ml blood was injected biweekly and then 5 ml biweekly in second week and in the third week 10 ml blood was given biweekly.[2]

We found that patients responded better to autohaemotherapy than to any other modalities. Itching subsided quickly, duration of weal was also decreased and interval between two episodes of the disease was increased from days to weeks.

Due to lack of satisfactory treatment and good results of autohaemotherapy it should be considered in the treatment of chronic urticaria but it needs further trials.

  References Top

1.Rook A. Urticaria. In: Textbook of Dermatology (Champion RH, Burton JL, Ebling FJG, eds). 5th edn. Oxford: Blackwell Scientific Publications, 1992;1865.  Back to cited text no. 1    
2.Behl P N. Autohaemotherapy. In: Practice of Dermatology 7th edn,1990:76.  Back to cited text no. 2    

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