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Year : 1995  |  Volume : 61  |  Issue : 5  |  Page : 268--269

Role of colchicine in primary localised cutaneous amyloidosis

1 Skin Clinic, 883, Jessore Road, Calcutta - 700055, India
2 Department of Dermatology, NRS Medical College, Calcutta - 700014, India

Correspondence Address:
K Chakravarty
Skin Clinic, 883, Jessore Road, Calcutta - 700055
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Source of Support: None, Conflict of Interest: None

PMID: 20952985

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Fifteen patients with primary localised cutaneous amyloidosis (PLCA), of which 8 had macular amyloidosis (MA) and 7 lichen amyloidosis (LA), received oral colchicine 1 mg/day in 2 divided doses for a period of 3 months. Pruritus completely disappeared in all MA patients and 30-60% diminution occurred in LA patients within 15 days. Intensity of pigmentation started to decrease within 7-14 days in all MA patients. Flattening of the papules anddiminution in thickness of the skin also started within one month in all LA patients, within 90 days of therapy pigmentation almost disappeared in all patients of MA and size of papules decreased by 80-98% in all LA patients. No significant side effect was seen in these patients due to colchicine therapy.


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Online since 15th March '04
Published by Wolters Kluwer - Medknow