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Year : 1995  |  Volume : 61  |  Issue : 4  |  Page : 239-240

Kyrle`s disease

Correspondence Address:
G Kalla

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Source of Support: None, Conflict of Interest: None

PMID: 20952972

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How to cite this article:
Kalla G, Kachhawa, Goyal M A, Mathur R D. Kyrle`s disease. Indian J Dermatol Venereol Leprol 1995;61:239-40

How to cite this URL:
Kalla G, Kachhawa, Goyal M A, Mathur R D. Kyrle`s disease. Indian J Dermatol Venereol Leprol [serial online] 1995 [cited 2020 Feb 19];61:239-40. Available from: http://www.ijdvl.com/text.asp?1995/61/4/239/4225

  To the Editor, Top

Kyrle's disease is a rare disorder of keratinization. It usually presents as multiple hyperkeratotic follicular and parafollicular papules with a central keratotic plug. The cause of disease is not known but it may be associated with diabetes, chronic renal failure and hepatic dysfunction.[1],[2]

A 23-year-old man presented with slowly progressive mildly pruritic, painless, discrete polygonal, symmetrical, hyperkeratotic papules of 0.5 cm to 1.0 cm size, on the extensors of upper limbs, lower limbs and on buttocks. In the centre of papules a cone shaped keratotic plug was present which was readily removed with the help of curette. Routine examinations of blood, urine and stool were within normal limits. Patient was not having diabetes mellitus, renal failure or hepatic dysfunction. The clinical diagnosis of Kyrle's disease was made which was subsequently confirmed by the histopathological examination by presence of hyperkeratosis and parakeratosis of epidermis and a keratinous mass seen penetrating the follicular wall at places with dermal infiltrate predominantly of lymphocytes.

It is thought that metabolic disorders associated with Kyrle's disease are somehow responsible for development of abnormal keratinization and connective tissue changes,[3]but the actual mechanism may be different as in our case the Kyrle's disease was seen in otherwise healthy adult male.

  References Top

1.Carter VH, Constantino VS. Kyrle's disease. I. Clinical findings in five case and review of literature. Arch Dermatol 1986;97:624-32.  Back to cited text no. 1    
2.Constantine VS, Carter VH. Kyrle's disease-II. Histological finding in five cases and review of literature. Arch Dermatol 1968;97:633-9.  Back to cited text no. 2    
3.Patterson JW. The perforating disorders. J Am Acad Dermatol 1984;10:561-81.  Back to cited text no. 3    


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