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Year : 1995  |  Volume : 61  |  Issue : 3  |  Page : 181-182

? Carbamazepine syndrome

Correspondence Address:
C Balchandran

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Source of Support: None, Conflict of Interest: None

PMID: 20952947

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How to cite this article:
Balchandran C. ? Carbamazepine syndrome. Indian J Dermatol Venereol Leprol 1995;61:181-2

How to cite this URL:
Balchandran C. ? Carbamazepine syndrome. Indian J Dermatol Venereol Leprol [serial online] 1995 [cited 2020 Feb 19];61:181-2. Available from: http://www.ijdvl.com/text.asp?1995/61/3/181/4200

  To the Editor, Top

This is with reference to the article 'Drug induced pseudolymphoma syndrome' (Ind J Dermatol Venereol Leprol 1994; 60:306-7). It is interesting to observe that the authors have seen about 3 cases of pseudolymphoma syndrome (PS) induced by carbamazepine. I wonder whether it should be called PS as carbamazepine is not known to cause that syndrome. The commonest drugs implicated are dilantin, mephenytoin, trimethadion, dihydralazine, captopril and isoniazid.[1] I fully agree with the authors that the clinical features were suggestive of PS. It would have been better to have done a skin and lymph node biopsy in all those cases to establish the diagnosis, since cutaneous pseudolymphomas mimick cutaneous malignant lymphomas histologically.[2],[3] In case 2, a lymph node biopsy was done, but the histopatholpgical features are not mentioned.

We have recently seen a 15-year-old boy who presented with fever, generalised erythematous macular lesions, lymphadenopathy and hepatitis, 15 days after starting carbamazepine for convulsions. All the investigations were within normal limits except for an abnormal LFT which showed raised bilirubin and enzyme levels. A skin biopsy and lymph node biopsy were not done as the patient showed remarkable improvement after starting treatment with 60 mg of prednisolone daily which was gradually tapered off. I feel it is a hypersensitivity reaction to carbamazepine and prefer the term 'carbamazepine syndrome' just like dapsone syndrome which manifests in a similar way. The diagnosis of PS should be based on skin and lymph node biopsies, a peripheral smear examination and bone marrow study.[4]

  References Top

1.Balachandran C: Phenytoin induced pseudo lymphoma syndrome. Ind J Dermatol Venereol Leprol 1992;58:53-4.  Back to cited text no. 1    
2.Connors RC, Ackerman AB. Histologic pseudomalignancies of the skin. Arch Dermatol 1976;112;1767-80.  Back to cited text no. 2    
3.Ackerman AB. Pseudolymphomas. In: Histologic diagnosis of inflammatory skin diseases (Ackerman AB, ed). Philadelphia:Lea & Febiger, 1978:442-7.  Back to cited text no. 3    
4.Braverman IM. Lymphomas and allied disorders. In: Skin signs of systemic disease (Braverman IM, ed). 2nd edn. Philadelphia: WB Saunders, 1981:109-78.  Back to cited text no. 4    


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