Indexed with PubMed and Science Citation Index (E) 
Users online: 4229 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  Navigate here 
   Next article
   Previous article 
   Table of Contents
 Resource links
   Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
   [PDF Not available] *
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

  In this article
   To the Editor...
   Article Figures

 Article Access Statistics
    PDF Downloaded0    
    Comments [Add]    
    Cited by others 1    

Recommend this journal


Year : 1995  |  Volume : 61  |  Issue : 1  |  Page : 65-66

Secondary syphilis with unusual skin manifestations

Correspondence Address:
Renu Roy

Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 20952888

Rights and PermissionsRights and Permissions

How to cite this article:
Roy R, Kalla G. Secondary syphilis with unusual skin manifestations. Indian J Dermatol Venereol Leprol 1995;61:65-6

How to cite this URL:
Roy R, Kalla G. Secondary syphilis with unusual skin manifestations. Indian J Dermatol Venereol Leprol [serial online] 1995 [cited 2019 Nov 12];61:65-6. Available from: http://www.ijdvl.com/text.asp?1995/61/1/65/4142

  To the Editor, Top

Syphilis 'The Great Imitator' is among the most fascinating of skin diseases. Cutaneous lesions of secondary syphilis are highly variable. Hyperkeratotic, crusted limpet like and discoloured lesions called rupia are uncommon and now usually seen in relapsing secondary syphilis. A typical case of hyperkeratotic syphilide is being reported.

A 24-year-old unmarried man was seen with a painless, hyperkeratotic crusted nodule on left forefoot [Figure - 1] and right second toe of one month duration, asymptomatic, symmetrical, annular lesions on sides of feet of 3 weeks duration and moist discrete papules in anogenital region of 10 days duration. There was history of primary chanre one month after sexual exposure about 2 years back and also history of recurrent asymptomatic rashes over trunk and genitalia in last 1 year subsiding with 3-4 days of minocycline prescribed by general practitioners. On examination there was generalized lymphadenopathy. VDRL test was reactive in 1:128 dilution, TPHA was positive, DGI from papules showed Treponema pallidum. Nodule biopsy revealed hyperkeratosis, acanthosis, dilatation and thickening of blood vessels, an increased number of large endothelial cells and the presence of a perivascular infiltrate containing plasma cells. Silver stain showed the presence of spirochaetes mainly within the epidermis and a few around the blood vessels of the superficial plexus. All the skin lesions disappeared in one month after 24 lac units of benzathine penicillin [Figure - 2][1][2].

  References Top

1.King A, Nicol C, Rodin P. Early Acquired Syphilis, Venereal disease, 4th Edn. ELBS, Bailliere Tindall, 1980,15-43.  Back to cited text no. 1    
2.Morton R S. The Treponematoses. In: Text Book of Dermatology (Champion RH, Burton JL, Ebling FJG, eds). 5th edn. Oxford: Blackwell Scientific publications, 1992;1082-126.  Back to cited text no. 2    


[Figure - 1], [Figure - 2]

This article has been cited by
1 Rupioid syphilis in a HIV patient
Bhagwat, P., Tophakhane, R., Rathod, R., Shashikumar, B., Naidu, V.
Indian Journal of Dermatology, Venereology and Leprology. 2009; 75(2): 201-202


Print this article  Email this article
Previous article Next article


Online since 15th March '04
Published by Wolters Kluwer - Medknow