Indexed with PubMed and Science Citation Index (E) 
Users online: 5034 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  Navigate here 
   Next article
   Previous article 
   Table of Contents
 Resource links
   Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   [PDF Not available] *
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

  In this article
   Case Report
   Article Figures

 Article Access Statistics
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal


Year : 1995  |  Volume : 61  |  Issue : 1  |  Page : 36-37

Verrucous cutaneous lupus erythematosus

Correspondence Address:
Mohan Devinder Thappa

Login to access the Email id

Source of Support: None, Conflict of Interest: None

PMID: 20952871

Rights and PermissionsRights and Permissions


An unusual case of cutaneous lupus erythematous with verrucous lesions is reported for its rarity and clinical interest.

Keywords: Lupus erythematosus, Verrucous

How to cite this article:
Thappa MD, Sri K V, Reddy B. Verrucous cutaneous lupus erythematosus. Indian J Dermatol Venereol Leprol 1995;61:36-7

How to cite this URL:
Thappa MD, Sri K V, Reddy B. Verrucous cutaneous lupus erythematosus. Indian J Dermatol Venereol Leprol [serial online] 1995 [cited 2019 Nov 22];61:36-7. Available from: http://www.ijdvl.com/text.asp?1995/61/1/36/4125

  Introduction Top

The spectrum of lupus erythematosus (LE) extends from the benign chronic cutaneous variety to the often fatal systemic type with nephritis.[1] Apart from the classical discoid lesions of cutaneous LE, less common expressions include verrucous,[2] lichenoid, bullous, LE profundus[3] and LE hypertrophicus et profundus.[4] Herewith, we report a case of LE with verrucous lesions for its rarity, diagnostic dilemma and therapeutic implications.

  Case Report Top

A 42-year-old man came with asymptomatic verrucous skin lesions over his extremities of 3 years duration. On examination, circumscribed, hyperkeratotic scaly plaques, 5 in number, of size 3-6cm, roughly circular in shape were seen over the forearms [Figure - 1], right knee and left foot. The scales over the plaques were thick, adherent and yellowish brown in colour. Some of the plaques showed atrophy, telangiectasia and depigmentation. The lower lip and buccal mucosa showed erosions with peripheral hyperpigmentation. Systemic examination was unremarkable.

Haemogram revealed anaemia (Hb 8.0gm) with eosinophilia. Renal and liver function tests and skiagram of chest were within normal limits. Serology for syphilis and LE cell phenomenon were negative. Biopsy of the Skin lesion (forearm) showed marked hyperkeratosis, acanthosis, follicular plugging with thinning of epidermis at places and focal dissolution of basal cell layer with melanin incontinence. Upper dermis showed lichenoid [Figure - 2] as well as patchy perivascular lymphohistiocytic infiltrate.

Based on the clinical and laboratory findings, the patient was diagnosed as verrucous cutaneous LE and advised topical corticosteriods. With little response later he was switched over to intralesional corticosteriods with good results.

  Discussion Top

Probably, the immune response of the host determines the clinical expression of LE and resultant clinical variants of cutaneous LE. Bechet[4] described a variant of chronic cutaneous LE under the name of LE hypertrophicus et profundus, as oval or rounded, sharply outlined, greatly elevated plateau like plaques with rolled borders, at times covered with thick adherent, digitate, verrucous hyperkeratotic scales. This destructive variant of discoid LE produces severe epidermal damage and dermal inflammation extending to the panniculus. LE profundus is another unusual variety of LE in which the cutaneous infiltrate occurs primarily in the deeper portion of the corium with only microscopic epidermal change giving rise to firm, sharply defined nodules lying beneath clinically normal or nearly normal skin.[3]

Clinical and histopathological features in our case were suggestive of verrucous (hypertrophicus) cutaneous LE as there was no involvement of panniculus or deeper corium.

Clinically the hyperkeratotic plaque can be mistaken for keratoachanthoma,[2] lichen planus hypertrophicus (LPH),[5] squamous cell carcinoma and tuberculosis verrucosa cutis.[6] Both LPH and cutaneous LE may cause atrophy or hypertrophy, exhibit photosensitivity and may involve buccal mucosa. Histologically both diseases are characterised by involvment of the basal layer of the epidermis, but moderate acanthosis and hyperkeratosis are seen more commonly ien LP than in LE.[7] Also the presence of severe itching and occurrence over the legs differentiates verrucous LP from discoid LE. Non-itchy hyperkeratotic scaly plaque lesions in our case showed in addition atrophy, depigmentation and microscopic features suggestive of discoid LE.

Topical fluorinated steroids, 5 Fluorouracil or retinoic acid produces little effect in verrucous lesion. Even oral chloroquine has not been found to be usuful. However intralesional steroids have been found to be most effective treatment,[2] including the case reported herein.

  References Top

1.Prystowsky SD, Herndon JH, Gilliam JN. Chronic cutaneous lupus erythematosus. Medicine 1975;55:183-93.  Back to cited text no. 1    
2.Uitto J, Santacruz DJ, Esien AZ. Verrucous lesions in patients with DLE. Br J Dermatol 1978;98:507-10.  Back to cited text no. 2    
3.Arnold HL. Lupus erythematosus profundus, Arch Dermatol 1956;73:15-33.  Back to cited text no. 3    
4.Bechet PE, Elizabeth NJ. Lupus erythematous hypertrophicus et profundus. Arch Dermatol 1950;61:495-8.  Back to cited text no. 4    
5.Romero RW, Nesbitt LT. Unusual variant of LE or LP. Arch Dermatol 1977;113:741-4.  Back to cited text no. 5    
6.Callen JP. Therapy of cutaneous lupus erythematous. Med Clin North Am 1982;66:795-807.  Back to cited text no. 6  [PUBMED]  
7.Daries MG, Gorkiewicz A, Knight A. Is there a relationship between LP and LE? Br J Dermatol 1977;96:145-9.  Back to cited text no. 7    


[Figure - 1], [Figure - 2]


Print this article  Email this article
Previous article Next article


Online since 15th March '04
Published by Wolters Kluwer - Medknow