|Year : 1995 | Volume
| Issue : 1 | Page : 32-33
A study of peripheral T-Lymphocytes in alopecia areata
RP Sharma, DK Sharma, NK Sharma, VK Pratap, Sharma
R P Sharma
Source of Support: None, Conflict of Interest: None
Estimation of peripheral T-lymphocytes (active and total) was carried out in 100 cases of alopecia areata as per method described by Boyam (1977) and West et al (1978). Clinically patients were divided in two groups, alopecia areata circumscribed (group I) and severe alopecia areata (group II). Thirty healthy subjects served as controls. Decrease in percentage of both active and total E-RFC was observed in 70% cases. The decrease was more significant in group II.
Keywords: Alopecia areata, T-lymphocytes
|How to cite this article:|
Sharma R P, Sharma D K, Sharma N K, Pratap V K, Sharma. A study of peripheral T-Lymphocytes in alopecia areata. Indian J Dermatol Venereol Leprol 1995;61:32-3
|How to cite this URL:|
Sharma R P, Sharma D K, Sharma N K, Pratap V K, Sharma. A study of peripheral T-Lymphocytes in alopecia areata. Indian J Dermatol Venereol Leprol [serial online] 1995 [cited 2019 Nov 22];61:32-3. Available from: http://www.ijdvl.com/text.asp?1995/61/1/32/4123
This article is a part of the paper entitled "Immunological Profile in Alopecia Areata" presented at VII International Congress of Dermatology held at New Delhi in February, 1994.
| Introduction|| |
The aetiology of alopecia areata remains obscure. Presently it is thought to be a disease of auto-immune aetiology. After going through some of such reports, present work was carried out to study the levels of peripheral-T-lymphocytes in the patients with alopecia areata.
| Materials and Methods|| |
The study comprised 100 cases of alopecia areata and 30 healthy controls of corresponding age and sex. On the basis of clinical observations patients were divided in two groups:
Group I: Alopecia areata circumscribed. Those having only few patches over scalp, face or body.
Group II: Severe alopecia areata. Those having multiple patches involving scalp, face and body for more than six months or multiple pathces with ophiasis or cases of alopecia totalis and universalis.
Estimation of peripheral-T-lymphocytes (active and total) was done by forming E-rosettes with sheep RBCs as per methods described by Boyam and West et al.
| Results|| |
Clinical observations revealed alopecia areata circumscribed in 75% and severe alopecia areata in 25% patients. The mean age of onset was 24 years with male/female ration of 1.6:1. The duration of disease ranged from 1 week to 25 years.
On estimation of peripheral T-lymphocytes, significantly decreased percentage of active and total E-REC levels were seen in 70 and 65 patients respectively as compared to controls
Out of 70 patients with decreased percentage of active E-REC, 21/25 belonged to clinical group II and 49/75 to group I, whereas out of 65 patients with decreased total E-RFC, 19/25 belonged to group II and 46/75 to group I.
Details of observation are shown in [Table - 1] and [Table - 2].
| Discussion|| |
Present study revealed decrease in percentage of both active and total E-RFC n upto 70% patients. The decrease was more significant in severe alopecia areata group (II) than in circumscribed alopecia areata group (I). Almost similar observations are reported by Brown et al, Giannetti et al, Friedmann and Singla et al. In contrast Gu et al, Thestrup-Pederson et al and Galbraith et al reported significant reduction in interactive-T-lymphocyte population in their patients.
It is concluded from the present study that decrease in percentage of both, active and total E-RFC levels indicated that cellular immunity was impaired in the patients under study.
| References|| |
|1.||Boyam A. Separation of lymphocytes, lymphocyte subgroups and monocytes. A review. Lymphology 1977;10:71-6. |
|2.||West WH, Boozer RB, Herberman RB. Low affinity E-rossetts formation by the human K cell. J Immunol 1978;120:90-5. [PUBMED] |
|3.||Brown AC, Olkowski ZL, Mclaren JR. Thymus lymphocytes of peripheral blood in patients with alopecia areata. Arch Dermatol 1977;114: 688. |
|4.||Giannetti A, Disilveri A, Castellazzi AM. Evidence for defective T cell function in patients with alopecia areata. Br J Dermatol 1978;98:361. |
|5.||Friedmann PS. Decreased lymphocyte reactivity and auto-immunity in alopecia areata. Br J Dermatol 1981;105:145-51. [PUBMED] |
|6.||Singla A, Mittal RR, Walia RLS, Bansal IJS. Selective immunological evaluation in alopecia areata. Ind J Dermatol Venereol Leprol 1991;57: 216-7. |
|7.||Gu SZ, Ros AM, Van Sledingk LV. T-cell subpopulation and their functions in vitro, a study in patients with alopecia areata and alopecia universalis. Int Arch Allergy App Immunol 1981;66:208-17. |
|8.||Thestrup-Pederson K, Bisballa S, Jensen JR. Immunological studies in patients with alopecia areata rrceivlng DNCB and cemetidine therapy. Arch Dermatol 1981;273:261-6. |
|9.||Galbraith GMP, Thiers BH, Vasily DB. Immunological profile in alopecia areata. Br J Dermatol 1984;110:163-70. |
[Table - 1], [Table - 2]