Indexed with PubMed and Science Citation Index (E) 
Users online: 3305 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  Navigate here 
   Next article
   Previous article 
   Table of Contents
 Resource links
   Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   [PDF Not available] *
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

  In this article
   Case Report

 Article Access Statistics
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal


Year : 1994  |  Volume : 60  |  Issue : 6  |  Page : 345-346

Non-diabetic atypical necrobiosis lipoidica

Correspondence Address:
R R Mittal

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions


One 8 year female child had asymptomatic, anaesthetic, hypohidrotic, atrophic, yellowish, waxy plaque on the front of left thigh since 2 months. No nerve thickening was observed clinically or histopathologically. Hyperkeratosis, follicular keratosis, epidermal atrophy, degeneration of collagen, mononuclear granulomas and perivascular mononuclear infiltrate confirmed the clinical diagnosis of atypical necrobiosis lipoidica.

Keywords: Necrobiosis of collagen, Granuloma

How to cite this article:
Mittal R R, Chopra A K, Walia R, Gill S S, Tapanjot. Non-diabetic atypical necrobiosis lipoidica. Indian J Dermatol Venereol Leprol 1994;60:345-6

How to cite this URL:
Mittal R R, Chopra A K, Walia R, Gill S S, Tapanjot. Non-diabetic atypical necrobiosis lipoidica. Indian J Dermatol Venereol Leprol [serial online] 1994 [cited 2020 Aug 11];60:345-6. Available from:

  Introduction Top

Necrobiosis lipoidica (NQ occurs in 0.3% of diabetics and between 2/3rd to 3/4th of NL patients have manifest diabetes. [1] Although, NL usually follows diabetes, the two conditions can develop simultaneously, and sometimes NL develop first. [1] NL is rare in early childhood. [2] 85% of non-diabetic NL patients are females. Typical plaques of NL are asymptomatic, round, firm, dull red with brownish red to violaceous margins and waxy yellow atrophic centres present on the shins. Plaque may have sclerodermiform appearance due to prominent fibrosis . [3] Eleven of 12 NL patients showed partial or complete anaesthesia of the affected plaque . [4] An intense and uniform hypohidrosis was observed in plaques on NL. [5]

  Case Report Top

A 8-years-female developed slowly progressive, yellowish, waxy, indurated, 4 cm x 3 cm oval plaque with ill-defined margins having irregular projections on its lateral side, in the middle of front of left thigh since 2 months. Plaque was uniformly hypohidrotic, anaesthetic, surface showed wrinkling, slight atrothv, and few black follicular keratotic plugs. There was no enlargement of peripheral cutaneous nerves or nerves ending in the lesion itself. She had Giardia infestation and anaemia which were treated. Caries teeth and seborrhoea capitis were present. She was born and has been living in Punjab since birth.

The girl was interrogated for a history suggestive of diabetes, especially regarding polyuria, thirst, increased appetite and weight loss, none of which was available. Her fasting blood sugar was 75 mg%. Glucose tolerance test was normal. Biopsy showed mild hyperkeratosis, follicular hyperkeratosis, mild atrophy of epidermis, papillomatosis and hyperpigmentation of the basal layer. Upper dermis showed foci of degeneration and regeneration of collagen, mononuclear granulomas with giant cells and perivascular mononuclear infiltrate. Dermal nerves were not thickened. No liquefaction degeneration of basal cells was seen. Transfollicular elimination of collagen could not be demonstrated clearly due to non-availability of specific stains.

  Comments Top

The present case presented with single, yellowish, wrinkled, anaesthetic, hypohidrotic, indurated plaque with irregular protrusion on its lateral side and discrete comedo-like plugs. Atypical NL, indeterminate leprosy and lichen sclerosis et atrophicus were considered in the differential diagnosis. Comedo-like plugs, atrophy of epidermis, negative smears and histopathology ruled out leprosy. Hypohidrosis, complete anaesthesia and absence of liquefaction degeneration of basal cells excluded lichen sclerosis et atrophicus. Awareness of atypical NL in the form of anaesthetic, yellow plaque studded with comedo-like plugs is important and such a presentation in an 8-year non-diabetic female is reported due to its rarity.

  References Top

1.Smith JG, Necrobiosis lipoidica : a disease of changing concepts. Arch Dermatol 1956;74:280-5.  Back to cited text no. 1    
2.Chernosky ME, Guin JD, Necrobiosis lipoidica in a three-year-old girl. Arch Dermatol 1961; 84:135-6.  Back to cited text no. 2    
3.Cunliffe WJ, Necrobiotic disorders. In: Textbook of Dermatology (Champion RH, Burton JL, Ebling FJG, eds), 5th edn. London: Blackwell Scientific Publishers, 1992, pp. 2033-8.  Back to cited text no. 3    
4.Mann RJ, Harman RRM. Cutaneous anaesthesia in necrobiosis lipoidica. Br J Dermatol 1984; 110: 323-5.  Back to cited text no. 4    
5.Hatzis J, Varelzidis A, Tosca A, et al. Sweat gland disturbances in granuloma annulare and necrobiosis lipoidica. Bri J Dermatol 1983; 108:705-9.  Back to cited text no. 5  [PUBMED]  


Print this article  Email this article
Previous article Next article


Online since 15th March '04
Published by Wolters Kluwer - Medknow