Brand-Ad-30-6
 IADVL
Indexed with PubMed and Science Citation Index (E) 
 
Users online: 13912 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
  Navigate here 
  Search
 
   Next article
   Previous article 
   Table of Contents
  
 Resource links
   Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
   [PDF Not available] *
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)  

 
  In this article
   Abstract
   Introduction
   Case Report
   Comments
   References

 Article Access Statistics
    Viewed4068    
    Printed49    
    Emailed0    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal

 


 
CASE REPORT
Year : 1994  |  Volume : 60  |  Issue : 5  |  Page : 290-291

Subcorneal pustular dermatosis and eosinophilia




Correspondence Address:
P Madavamurthy


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

  Abstract 

A young male having subcorneal pustular dermatosis is reported. The patient had characteristic skin lesions associated with itching and had typical histopathological changes. Patient also had peripheral eosinophilia and showed dramatic response to Dapsone.


Keywords: Subcorneal pustular dermatosis, Eosinophilia


How to cite this article:
Madavamurthy P, Siddappa K, Chandrasekhar H R, Ravi. Subcorneal pustular dermatosis and eosinophilia. Indian J Dermatol Venereol Leprol 1994;60:290-1

How to cite this URL:
Madavamurthy P, Siddappa K, Chandrasekhar H R, Ravi. Subcorneal pustular dermatosis and eosinophilia. Indian J Dermatol Venereol Leprol [serial online] 1994 [cited 2020 Aug 5];60:290-1. Available from: http://www.ijdvl.com/text.asp?1994/60/5/290/4079



  Introduction Top


Subcorneal pustular dermatosis (SCPD) is seen more among women over 40 years of age, [1] though the disease is rather uncommon and there are few cases reported among children [2]. We are repoting a 22 year old male patient of SCPD with peripheral eosinophilia because of its rarity.


  Case Report Top


A 22-years-old male patient presented with recurrent attacks of mildly pruritic pustular eruptions on the trunk and extremities of 5 years duration. Initially the lesions appeared on the inner aspect of the right arm and within a span of 1 week similar lesions appeared on the trunk, inner aspect of the upper arms, and the thighs. The lesions used to disappear in 3-4 weeks time with hypopigmentation at the site. The lesions were associated with mild to moderate itching and not associated with constitutional symptoms. There was no seasonal variation. Patient was under treatment by general practitioners. There was no history of any other illness. Routine laboratory investigations of blood,urine and stool were within the normal limits except for eosinophilia (differential eosinophil count - 20%, Absolute eosnophil count - 1.200 cells/cu. mm). Chest X-ray was normal. Tzank test did not show any acantholytic cell. Histopathological study of the fresh lesion revealed a subcorneal pustule filled with neutrophils. There was not acantholysis and dermis was normal.

The lesions started disappearing after 1 week treatment with dapsone 100 mg daily. When the patient himself stopped taking the drug there was recurrence which responded after restarting the drug.


  Comments Top


The characteristic morphology of the lesions and the typical sites of distribution suggested a diagnosis of SCPD which was confirmed by histopathology and a dramatic response to dapsone. The recurrence of the lesions after restarting also supports the diagnosis.

Though SCPD is more common in women and in persons over 40 years of age it may occur in any age. [3] Kanwar et al [4] from Libya reported 2 cases of SCPD in younger patients which tallies with reports from India where SCPD appears to occur more commonly in males and in a relatively younger age group.

SCPD has been reported in association with IgA gammopathy, pyoderma gangrenosum, psoriasis, diabetes mellitus and hypothyroidism. [5],[6],[7],[8] The association of SCPD with eosinophilia may be fortuitous but merits further study.

 
  References Top

1.Snedden IB, Wilkinson DS. Subcorneal pustular dermatosis. Br J Dermatol 1979; 100:61-8.  Back to cited text no. 1    
2.Johnson SAM, Cripps JD. Subcorneal pustular dermatosis. Arch Dermatol 1974; 109: 73.  Back to cited text no. 2    
3.Honigsmann H, Wolff K. Subcorneal pustular dermatosis, In : Dermatology in general medicine. Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austin FK. eds. 3rd ed. New York : McGraw-Hill Information Services, 1987; 601-4.  Back to cited text no. 3    
4.Kanwar AJ, Malkit Singh, Ibtesam Mahadi, et al. Subcorneal pustular dermatosis. Indian J Dermatol Venereol Leprol 1987; 53: 239-40.  Back to cited text no. 4    
5.Cream JJ, Grimes SM, Roberts PD. Subcorneal pustular dermatosis and IgA myelomatosis. Br med J 1977; i : 550.  Back to cited text no. 5    
6.Marsden JR, Millard LG. Pyoderma gangrenosum, subcorneal pustlar dermatosis and IgA paraproteinemia. Br J Dermatol 1986; 114: 125-9.  Back to cited text no. 6  [PUBMED]  
7.Sanchez NP, Perry HO, Muller SA, Winkelman RK. Subcorneal pustular dermatosis and pustular psoriasis. Arch Dermatol 1983; 119: 715-21.  Back to cited text no. 7    
8.Tagami H, Iwatsuki K, Iwase Y, Yamada M. Subcorneal pustular dermatosis with vesiculobullous eruption. Demonstration of subcorneal IgA deposits and a leukocyte chemotactic factor. Br J'Dermatol 1983; 109:581-9.  Back to cited text no. 8  [PUBMED]  




 

Top
Print this article  Email this article
Previous article Next article

    

Online since 15th March '04
Published by Wolters Kluwer - Medknow