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   Abstract
   Introduction
   Case Report
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CASE REPORT
Year : 1994  |  Volume : 60  |  Issue : 3  |  Page : 151-152

Multiple cutaneous horns arising from porokeratosis




Correspondence Address:
Najeeba Riyaz


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Source of Support: None, Conflict of Interest: None


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  Abstract 

Development of cutaneous horns in lesions of congenital linear porokeratosis in a 65 year old lady is described.


Keywords: Linear porokeratosis, Cutaneous horns


How to cite this article:
Riyaz N, Nair V L. Multiple cutaneous horns arising from porokeratosis. Indian J Dermatol Venereol Leprol 1994;60:151-2

How to cite this URL:
Riyaz N, Nair V L. Multiple cutaneous horns arising from porokeratosis. Indian J Dermatol Venereol Leprol [serial online] 1994 [cited 2019 Jun 20];60:151-2. Available from: http://www.ijdvl.com/text.asp?1994/60/3/151/4024



  Introduction Top


Cutaneous horn is an uncommon lesion of unknown etiology and probably represents a rection pattern. It primarily occurs on sun­exposed areas, associated with cutaneous actinic damage and rarely progresses into malignancy. [1] Porokeratosis is a unique hereditary disturbance characterized by keratotic lesions with a wall like horny border and an atrophic centre. The occurrence of cutaneous horns in porokeratosis to the best of our knowledge, has not been reported earlier.


  Case Report Top


A 65-years-old lady was seen with a history of multiple keratotic papules and plaques on the left lower limb since birth. Gradually new lesions developed in a linear pattern and involved the whole extremity. Individual lesions extended and coalesced to form plagwes. Some of the lesions resolved without any trace. She had tried different treatment modalities but there was no relief. 2 months back she noticed multiple horny projections from the centre of several lesions of the left leg. Some of them were very painful. On examination, multiple keratotic papules and plaques with raised horny margins, some with an atrophic centre of size varying from 0.5 to 2.5 cms, were seen on the anterior and lateral aspects of the left thigh, leg and foot. Several lesions on the leg showed central horny projections of 1.5 to 2 cms in length. Systemic examination was normal. The skin biopsy of a lesion from the left leg showed a conical hyperkeratosis and a keratin filled invagination of the epidermis with a cornoid lamella in the centre. The dermis showed a perivascular mononuclear infiltrate. There was no evidence of malignant transformation.


  Comments Top


Linear porokeratosis has an autosomal dominant inheritance and lesions usually start in childhood or may be present at birth. Development of a squamous cell carcinoma or of Bowen's disease has been reported in linear [3] and disseminate forms . [4]

The clinical significance of a cutaneous horn is uncertain. What is important is the lesion at the base of a horn, which may be malignant or pre-malignant. Actinic keratosis was the most common lesion found at the base in one study. [2] Horns may also be found overlying warts, squamous cell carcinoma, seborrhoeic keratoses and rarely trichilemmoma or a basal cell epithelioma.

Though the cutaneous horn is a result of dysplastic epidermal changes, histologically there is no atypicality or loss of polarity. In long standing lesions it may show evidence of malignant transformation to a squamous cell carcinoma as evidenced by budding from the basal layer. Whether the cutaneous horns are forerunners of malignancy in our patient needs follow up.

 
  References Top

1.Pinkus H. Keratosis senilis. Am J Clin Pathol 1958; 29 : 193 - 207.  Back to cited text no. 1  [PUBMED]  
2.Schosser RH, Hodge SJ, Gaba CR, et al. Cutaneous horn-Histopathological study. South Med J 1979; 72 : 1129-31.  Back to cited text no. 2  [PUBMED]  
3.Coskey RJ, Mehregan A. Bowen disease associated with porokeratosis of Mibelli. Arch Dermatol 1975; 111 : 1480-1.  Back to cited text no. 3  [PUBMED]  
4.Guss S B, Osbourn R A, Lutzner M A. Porokeratosis plantaris palmaris et disseminate. Arch Dermatol 1971 ; 104 366-73.  Back to cited text no. 4    


    Figures

[Figure - 1], [Figure - 2]

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1 Premalignant and early squamous cell carcinoma
Butani, A., Arbesfeld, D.M., Schwartz, R.A.
Clinics in Plastic Surgery. 2005; 32(2): 223-235
[Pubmed]
2 The actinic keratosis: A perspective and update
Schwartz, R.A.
Dermatologic Surgery. 1997; 23(11): 1009-1019
[Pubmed]



 

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