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Year : 1994  |  Volume : 60  |  Issue : 2  |  Page : 110-111

Eccrine gland adenocarcinoma in albinism

Correspondence Address:
H Hanumanthappa

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A case of eccrine gland adenocarcinoma is reported in adult male albinism patient.

Keywords: Eccrine gland adenocarcinoma, Salivary gland metastases

How to cite this article:
Hanumanthappa H. Eccrine gland adenocarcinoma in albinism. Indian J Dermatol Venereol Leprol 1994;60:110-1

How to cite this URL:
Hanumanthappa H. Eccrine gland adenocarcinoma in albinism. Indian J Dermatol Venereol Leprol [serial online] 1994 [cited 2020 Sep 30];60:110-1. Available from:

  Introduction Top

Incidence of eccrine gland carcinoma is relatively rare. [1] The classic type of eccrine gland adenocarcinoma has a high incidence of metastases, particularly to regional lymphnodes and rarely visceral metastases are seen. [2]

Among the neoplasms of sweat glands a study of 50 cases were accounted during a period of 27 years in which 3 cases were eccrine gland carcinomas. [3]

In another study only 5 cases were reported stating that incidence of eccrine gland

carcinoma was rare . [4]

  Case Report Top

A 28-year-old male albinism patient born to consanguineous married parents was presented with nodulo-ulcerative lesion over forehead, left ear and swelling in the left mandibular region of 9 months duration in a chronological order. To start with, a small painless nodular lesion appeared over the centre of forehead which broke open to produce an ulcer [Figure - 1]. After 2 months similar lesion had appeared over left ear. 15 days later a small swelling appeared over the left submandibular region and went on increasing in size gradually. History of mild pain particularly during chewing of food was present. History of photosensitivity was present. No history of loss of weight and appettite.

Patient had 2 sisters and 1 brother. One sister was affected by albinism. Parents were normal.

Cutaneous examination revealed noduloulcerative lesion over centre of forehead measuring 2.5 cms x 0.75 cms, mobile, mildly tender, serosanguinous discharge was present. Ulcerative plaque with verrucous surface was seen over left ear. Swelling in the left submandibular region of 5 cms x 3 cms in size was present. Firm to hard in consistency, non­tender and freely mobile. Patient had oculo­cutaneous albinism. Systemic examination was normal.

Routine investigations were within normal limits. Skin biospy (forehead), showed eccrine glandular structures with multiple group of tumor cells with hyperchromatic nuclei with prominent nucleoli and the tumor cells were separated by fibrous tissue septa, suggestive of adenocarcinoma of eccrine gland [Figure - 2]. Biopsy from submandibular swelling revealed salivary gland with tumor cells of eccrine gland separated by fibrous septa.

  Comments Top

Common tumors which occur in Albinism patients are squamous cell carcinoma and basal cell carcinoma. Matastases of eccrine gland in to the regional lymphnodes can take place [2]. But in our patient metastases was seen in the submandibular salivary gland, which is an interesting manifestation.

  References Top

1.Lever WF, Schaumburg - Lever G. In : Histopathology of the skin, 7th edn. Philadelphia: JB Lippincott, 1990: 635.  Back to cited text no. 1    
2.Mackie R M. Tumors of skin appendages. In Text book of Dermatology (Rook A, Wilkinson DS, Ebling FJG, et al, eds), 5th edn. London : Blackwell Scientific Publications, 1992; 1522.  Back to cited text no. 2    
3.Solanki R L, Anand V K, Gupta R, Arora H L, Gaur S K. Neoplasms of sweat glands. Ind J Dermatol Venereol Leprol 1989; 55 : 108-12.  Back to cited text no. 3    
4.Vaishnav V P, Dharkar D D. Adnexal tumors of skin. Ind J Pathol Bacteriol 1955; 71 : 361-72.  Back to cited text no. 4    


[Figure - 1], [Figure - 2]


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