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 STUDIES
Year : 1993  |  Volume : 59  |  Issue : 4  |  Page : 168--171

Oral colchicine in chronic plaque psoriasis



Correspondence Address:
Prasanta Bassak


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Colchicine is well known for its antimitotic and anti-inflammatory effects. This study was designed to evaluate the role of oral colchicine in chronic plaque psoriasis. Fifty adults with chronic plaque psoriasis were randomly allocated into 2 groups of 25 patients each. Group A received oral colchicine 2 mg/day in 2 divided doses, while Group B patients were given placebo tablets. Patients were evaluated every week and the final result compiled after 8 weeks. 90% patients in Group A had gastrointestinal intolerance necessitating a reduction in dose of colchicine to 1 mg/day. After 8 weeks the lesions improved significantly in Group - A patients, compared to Group B (t=2.815, p<0.01). Apart from gastrointestinal intolerance and nephrotic syndrome, no other significant side effects were encountered. It may be worthwhile trying this drug in chronic plaque psoriasis recalcitrant to conventional topical treatment.






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Online since 15th March '04
Published by Wolters Kluwer - Medknow