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  In this article
   Abstract
   Introduction
   Case Report
   Comments
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CASE REPORT
Year : 1993  |  Volume : 59  |  Issue : 1  |  Page : 17-18

Familial giant reactive perforating collagenosis




Correspondence Address:
Dilip Kachhawa


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  Abstract 

A 21-year old man presented with slowly growing, multiple, recurrent, discrete, asymmetrical hyperkeratotic and hyperpigmented papules of size varying between 10-15mm over face and upper limbs; usually after trauma. Histopathology confirmed the diagnosis of reactive perforating collagenosis. This case is reported because of unusual bigger size of the lesions.


Keywords: Reactive perforating collagenosis


How to cite this article:
Kachhawa D, Kalla G, Dingra BB. Familial giant reactive perforating collagenosis. Indian J Dermatol Venereol Leprol 1993;59:17-8

How to cite this URL:
Kachhawa D, Kalla G, Dingra BB. Familial giant reactive perforating collagenosis. Indian J Dermatol Venereol Leprol [serial online] 1993 [cited 2019 Oct 15];59:17-8. Available from: http://www.ijdvl.com/text.asp?1993/59/1/17/3869



  Introduction Top


Reactive perforating collagenosis (RPC) is a form of transepidermal elimination in which altered collagen is extruded from the epidermis. The disease usually starts as papules in early childhood. The papules develop umbilications with keratinous plugs. We report a case of RPC with a positive family history. The size of umbilicated papules was abnormally bigger, therefore we have named it giant RPC.


  Case Report Top


A 21- year-old man presented with slowly growing, multiple, recurrent, discrete, asymmetric, hyperkeratotic and hyperpigmented papules of size varying between 10-15 mm, over the face and upper limbs. The eruption started at the age of 15 years. Initially a skin-coloured papule appeared on dorsum of right finger which soon developed central umbilication filled with a keratinous plug which was initially adherent but soon became loose and finally fell off. Involution of lesion occurred with hyperpigmentation and epidermal atrophy.

Different stages of evolution and regression were seen at the same time, the lesions were showing Koebner's phenomenon. These lesions occurred at sites of acne, minor trauma because of shaving, and sometimes

Family history of such lesions was present in younger brother of 9 years who developed these lesions since early childhood. No history of diabetes, hepatic, renal or other systemic disorders was present.

Routine investigations were normal. Biopsy of the initial non- umbilicated papule showed an area of necrobiotic, deeply basophilic collagen in the papillary dermis. The old umbilicated lesion in which the plug was eliminated showed a central area of depression, an accumulation of parakeratotic keratin, basophilic collagen, and numerous pyknotic nuclei of inflammatory cells. The epidermis at the base of the plug was atrophic and showed perforation through which basophilic bundles of collagen extending upwards were extruded from the underlying dermis. This was confirmed by staining with von Gieson method. The periphery of the cup-shaped lesion showed epidermal hyperplasia. The elastic fibres were normal and seen only in the dermis.


  Comments Top


According to Mehregan et al [1] RPC is an abnormal response to superficial trauma in which collagen causes irritation and perforation of the epidermis with transepidermal elimination.

Formation of giant lesions in RPC may be associated with increasing age as the younger brother of our patient had smaller lesions. Familial occurrence of RPC has been recorded only in some cases. [2],[3],[4],[5]

 
  References Top

1.Mehregan AH, Schwartz OD,Livinggood CS. Reactive perforating collagenosis. Arch Dermatol 1967; 96: 277-82.  Back to cited text no. 1    
2.WeinerAL. Reactive perforating collagenosis. Arch Dermatol 1970; 102: 540-4.  Back to cited text no. 2    
3.Kanan MW. Familial reactive perforating collgenosis, intolerance to cold. Br J Dermatol 1974; 91: 405-14.  Back to cited text no. 3  [PUBMED]  
4.Pasricha JS, Girgla HS, Kandhari KC. Reactive perforating collagenosis. Dermatologica 1971; 143: 353-6.  Back to cited text no. 4  [PUBMED]  
5.Kalla G, Malhotra Y K, Vyas MCR, Kothari A, Suhail A. Reactive perforating collagenosis. Ind J Dermatol Venereol Leprol 1989; 55: 258-9.  Back to cited text no. 5    


    Figures

[Figure - 1]

This article has been cited by
1 Familial reactive perforating collagenosis
Bhat, Y.J., Manzoor, S., Qayoom, S., Wani, R., Baba, A.N., Bhat, A.H.
Indian Journal of Dermatology. 2009; 54(4): 334-337
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2 Familial reactive perforating collagenosis: A case report
Kumar, V., Mehndiratta, V., Sharma, R.C., Narayan, S., Koranne, R.V., Kakar, N.
Journal of Dermatology. 1998; 25(1): 54-56
[Pubmed]



 

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