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   Abstract
   Introduction
   Material and Methods
   Results
   Comments
   References

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SHORT COMMUNICATION
Year : 1992  |  Volume : 58  |  Issue : 4  |  Page : 260-261

Immunological study of Pityriasis versicolor and Pityrosporum folliculitis




Correspondence Address:
R R Mittal


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Source of Support: None, Conflict of Interest: None


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  Abstract 

Twenty five cases of pityriasis versicolor and 25 cases of pityrosporum folliculitis were selected for this study. Skin scrapings in 10% potassium hydroxide showed spores and hyphae in all 25 cases of PV. Smears from PF showed Gram positive spores in all 25 cases and in addition few short hyphae in 3 cases. Initially IgM and Later both IgM and IgG were raised. Similar response was seen in PF initially and later IgM, IgG and IgA all were raised in PF. Though antibody levels were slightly higher in PF, yet basically the pattern was similar in PV and PF.


Keywords: Pityriasis versicolor, Pityrosporum folliculitis, Antibodies


How to cite this article:
Mittal R R, Singh P, Prasad D. Immunological study of Pityriasis versicolor and Pityrosporum folliculitis. Indian J Dermatol Venereol Leprol 1992;58:260-1

How to cite this URL:
Mittal R R, Singh P, Prasad D. Immunological study of Pityriasis versicolor and Pityrosporum folliculitis. Indian J Dermatol Venereol Leprol [serial online] 1992 [cited 2019 Sep 17];58:260-1. Available from: http://www.ijdvl.com/text.asp?1992/58/4/260/3812



  Introduction Top


Pityrosporum orbiculare and Pityrosporum ovate are 2 names of the same organism and it leads to 2 distinct dermatoses namely pityriasis versicolor (PV) and Pityrosporum folliculitis (PF) [1]. Antibodies against Pityrosporum were found to be raised in PV [2] in one study. However, another study reported that levels of antibodies between PV cases and normal adult controls were not different. [.3] The mean serum antibody titre was found to be significantly higher than healthy controls in PF in one study. [4] T and B lymphocytes and sub population of T cells in blood were normal. [5]


  Material and Methods Top


Twenty five cases each of PV and PF were selected. Skin scraping in 10% potassium hydroxide (KOH) were examined in PV. Skin smears from pus of follicular pustules were stained with Gram's stain.

Quantitative serum immunoglobulins (IgG, IgM, and IgA) were estimated by single radial immunodiffusion technique by using Tri-partigan plates supplied by Hoechst - pharmaceuticals in all the 50 cases.

T and B lymphocytes in peripheral blood were studied according to method described by Thompson (1977) in all the 50 cases.


  Results Top


Skin scrapings in 10% KOH showed spores and hyphae in all 25 cases of PV and smears showed Gram-positive spores in all 25 cases of PF. In 3 cases of PF, in addition to spores, few short hyphae were seen.

in all 50 cases antibodies of one or more class were raised and decreased levels were not seen in any case.

In 12 (48%) cases of PV (Group A) only IgM was raised and in the remaining 13 (52%) both IgG and IgM were raised and this increase in antibodies was statistically significant. In 8 cases of PV with duration of less than I year (group I) only IgM was raised, in 15 cases with duration of 1 to 5 years (group II) and in 2 cases with duration of more than 5 years (group III) both IgG and IgM were raised. So initial increase was in levels of igM and later in both IgG and IgM levels. On comparison of group I with II and group II with III, the differences were statistically significant and so antibodies increased consistently with increase in duration of PV.

Six (24%) cases of PF (group B) had raised IgM levels, 15 (60%) had raised IgG and IgM, 2 (8%) had raised levels of IgM and IgA and rest 2 (8%) had raised levels of IgG, IgM, and IgA and increase in antibodies was statistically significant. Two cases of PF with duration of less than one year (group I) had raised levels of IgM, of the 21 cases with duration of 1 to 5 years (group II), 4 had raised IgM, 15 had raised IgM and IgG, and 2 had raised IgM and igA levels. Two cases with duration of more than 5 years (group III) had increased levels of IgG, IgM, and IgA. On comparison of group I with II and group II with III, the differences were statistically significant and so increase in antibodies was more and consistent with increase in duration of PF.

On comparison between group A and B it was found that IgG was statistically significantly more raised 4n group B while the differences in IgM and IgA levels in 2 groups were not significant.

Mean peripheral T lymphocytes count in controls was 55.8, in PV, it was 54.44 and in PF it was 54.64 and statistically T lymphocytes were within normal range in both PV and PF.

Mean of peripheral B lymphocytes in controls was 31.6, in PV 31.76 and in PF 31.31 and statistically B lymphocytes were within normal range in both PV and PF.


  Comments Top


This study revealed that cell-mediated immune response studied indirectly by peripheral T and B-lymphocyte counts was normal. Humoral response was in the form of raised antibodies in both PV and PF. In both PV and PF initial increase was in IgM and later IgG was also raised. However in PF, in addition, IgA was also raised in 4 (16%) cases. In both PV and PF, antibodies increased steadily with increase in duration of disease. So, inspite of the diversity in clinical and histological picture in PV and PF caused by same pathogen, interestingly immunological response of host was similar.

 
  References Top

1.Porro MN, Passin S, Caprilli F, et al. Induction of hyphae in cultures of pityrosporum by cholesterol and cholesterol esters. J Invest Dermatol 1977;69: 531 - 4.  Back to cited text no. 1    
2.Sohnle RG, Collisis LC. Relative antigenicity of Pityrosporum orbiculare and Candida albicans. J Invest Dermatol 1980; 75: 279 - 83.  Back to cited text no. 2    
3.Faergemann J. Antibodies to Pityrosporum orbiculare in patient with tinea versicolor and controls of various ages. J Invest Dermatol 1983; 80: 133-5.  Back to cited text no. 3  [PUBMED]  
4.Faergemann J, Johansson S, Bach 0, et al. An immunologic and cultural study of Pityrosporum folliculitis. J Am Acad Dermatol 1986; .14: 429-33.  Back to cited text no. 4    
5.Scheynius A, Faergemann J, Forsum U, et al. Phenotypic characterization in sites of inflammatory cells in pityriasis versicolor. Acta Derm - venereol 1984; 64: 473 - 7.  Back to cited text no. 5  [PUBMED]  




 

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