Indexed with PubMed and Science Citation Index (E) 
Users online: 106 
     Home | Feedback | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe What's New Contact  
    Next article
    Previous article
    Table of Contents

    Similar in PUBMED
    Search Pubmed for
    Search in Google Scholar for
  Related articles
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal


Year : 1992  |  Volume : 58  |  Issue : 1  |  Page : 15--19

Methotrexate-puvasol combination in treatment of psoriasis


Correspondence Address:
S Talwar

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Get Permissions

Get Permissions

Patients with severe psoriasis were divided into 2 groups. In group A, consisting of 30 patients, remissions were induced by short term use of combination therapy consisting of methotrexate (5 mg every 12 hours x 3 doses per week) + psoralen (30 mg on alternate days) and sun exposure (PUVASOL). Thereafter, remission was maintained by use of minimal possible PUVASOL treatment alone. However, flare-ups during maintenance-phase were controlled by short term addition of methotrexate. Remission was induced in all these cases after a mean of 5.1 weeks (range, 3 - 9 weeks) of treatment using a mean total dose of 74.6 mg of methotrexate along with PUVASOL. During maintenance phase, recurrence was observed in 19 of these patients after a mean of 4.6 months. These recurrences were again controlled by clearance courses of methotrexate. On an average 1 - 6 (mean, 4) clearance courses were required during a period of 2 years. In group B, consisting of 10 patients, remission was induced by use of methotrexate alone and after achievement of remission methotrexate was withdrawn. Comparatively I did not find any significant advantage of adding PUVASOL for clearance of the lesions. However, during follow-up all patients in group b reported with recurrence much earlier. I recommend the use of methotrexate alone for clearance of lesions in severe psoriasis and PUVASOL alone in maintenance phase to prevent relapse.

[FULL TEXT] [PDF Not available]*

Print this article     Email this article

Online since 15th March '04
Published by Wolters Kluwer - Medknow