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SHORT COMMUNICATION
Year : 1991  |  Volume : 57  |  Issue : 6  |  Page : 311

Disseminated discoid lupus erythematosus treated with dexamethasone pulse therapy



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O P Singh


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How to cite this article:
Singh O P. Disseminated discoid lupus erythematosus treated with dexamethasone pulse therapy. Indian J Dermatol Venereol Leprol 1991;57:311

How to cite this URL:
Singh O P. Disseminated discoid lupus erythematosus treated with dexamethasone pulse therapy. Indian J Dermatol Venereol Leprol [serial online] 1991 [cited 2019 Jun 25];57:311. Available from: http://www.ijdvl.com/text.asp?1991/57/6/311/3719


Various therapeutic modalities are avail­able for the treatment of discoid lupus erythematosus. [1],[2] Here is a brief report of a case of disseminated discoid lupus erythematosus (D D L E) which has not re­sponded earlier to , antimalarials, antihistaminics and topical steroids.

A-40-year old gardener with progressive D D L E on the. face, exposed areas of the ex­tremities and neck for 6 years, was confirmed by skin biopsy. He was put on pulse therapy consisting of 100 mg of dexamethasone in 5% dextrose, given intravenously for three con­secutive days in a month. After 9 pulses there was about 50% improvement and after 15 pulses the patient had more than 90% im­provement. There were no side effects of the treatment. Pulse therapy has been used for the first time in D D L E to assess its effi­cacy. The result of dexamethasone pulse therapy n this patient of D D L E is encour­aging and promising.

 
  References Top

1.Rowell NR : Lupus erythematosus, Scleroderma and Dermatomyositis, Connective Tissue Diseases, in : Text Book of Dermatology, Fourth Ed Rook A, Wilkinson DS, Ebling FJG et al; (Eds) Oxford University Press, Bombay, 1987 ; P 1300-1302.  Back to cited text no. 1    
2.Pye RJ, RobertsSOB and Champion RH : Sys­temic therapy, in : Text Book of Dermatology, Fourth Ed, Rook A, Wilkinson DS, Ebling FJG et al :(Eds) Oxford University Press, Bombay, 1987 ; P 2502.  Back to cited text no. 2    



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Indian Journal of Dermatology, Venereology and Leprology. 2008; 74(2): 171-173
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2 Dexamethasone pulse therapy in dermatology
Ramam, M.
Indian Journal of Dermatology, Venereology and Leprology. 2003; 69(5): 319-322
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