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Year : 1991  |  Volume : 57  |  Issue : 3  |  Page : 162

Darier's disease

Correspondence Address:
M M Udagani

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How to cite this article:
Udagani M M, Siddaramappa B, Shankar R, Swamy B. Darier's disease. Indian J Dermatol Venereol Leprol 1991;57:162

How to cite this URL:
Udagani M M, Siddaramappa B, Shankar R, Swamy B. Darier's disease. Indian J Dermatol Venereol Leprol [serial online] 1991 [cited 2020 Aug 13];57:162. Available from:

To the Editor,

 Darier-White disease More Details is determined by autosomal dominant gene or it is determined by mutation of gene[1]. The follicular and non follicular hyperkeratotic papules with waxy scales are constant features. The occurrence of multiple hypo-pigmented macules in Darier s disease is uncommon[2]. There are 3 earlier reports from India and abroad[3],[4],[5] We are re­porting such case because of its rarity.

A male aged 35, farmer by occupation had skin lesions for the last 15 years. The skin lesions were more in the summer. There are no other family members suffering from such condition. On examination, there were follicular, non-follicular, pin-head size to 2 mm diameter pigmented hyperkeratotic papules present over the scalp, face, shoulders and neck. Palms, soles and nails were normal. There were multiple hypopigmented macules of 1-3 mm in diameter present over the ante­rior and posterior aspect of trunk and thighs. All routine investigations were within normal limits. VDRL - non-reactive. X-ray chest was normal. Histopathological examinations of keratotic lesion revealed typical suprabasal cleft with acantholytic cells and few dyskeratotic cells.

  References Top

1.Lever WF and Schaumburg-Lever G : Congenital diseases (Genodermatoses), in : Histopathology of Skin, 6th Ed, JB Lippincott Company, Philadelphia, 1983; p 70.  Back to cited text no. 1    
2.Rook A, Wilkinson DS and Ebling FJG : Textbook of Dermatology, 3rd Ed, Blackwell Scientific Pub­lications, Oxford, 1979; p 1292.  Back to cited text no. 2    
3.Cornelison RL, Smith EB and Knox JM : Guttate leukoderma in Darier's disease, Arch Dermatol, 1970; 102 : 447-450.  Back to cited text no. 3    
4.Bedi BMS and Garg BR : Darier's disease, Ind J Dermatol Venereol Leprol, 1978; 44 : 145-148.  Back to cited text no. 4    
5.Garg BR and Sait MA : Unilateral Darier's disease, Ind J Dermatol Venereol Leprol, 1985; 51 : 289­291.  Back to cited text no. 5    


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