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Year : 1991  |  Volume : 57  |  Issue : 1  |  Page : 51

Evaluation of 5-fluorouracil in treatment of warts

Correspondence Address:
S P Chattopadhyay

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How to cite this article:
Chattopadhyay S P, Das P K. Evaluation of 5-fluorouracil in treatment of warts. Indian J Dermatol Venereol Leprol 1991;57:51

How to cite this URL:
Chattopadhyay S P, Das P K. Evaluation of 5-fluorouracil in treatment of warts. Indian J Dermatol Venereol Leprol [serial online] 1991 [cited 2020 Jul 15];57:51. Available from:

Electrodessication is one of the foremost method for treatment of verruca vulgaris but it produces scars and recurrences. Condylomata accuminata is usually treated with 25% podo­phyllin with painful ulceration & variability in re­sponse and recurrence.

In this study topical 5% 5 fluorouracil cream was evaluated. Fluorouracil is flurinated pyrimi­dine and it interfers with DNA synthesis by decreasing the availability of thiamine[1]. In a double blind study 5% 5 fluorouracil was found superior to placebo in the treatment of verruca vulgaris.[2] By applying 5% 5 fluorouracil twice daily for 3 weeks a cure rate of 25% for meatal warts, 36% for preputial and 71% for penile skin warts was achieved[3].

  Material and Methods Top

Out of fifty cases of condylomata accuminata selected at random, 25 cases were treated with topical 5% 5 fluorouracil USP in cream base for 8 hours daily for 2-3 weeks. The remaining 25 cases were treated with 25% podophyllin in Tinc benzoin for 8 hours for 2 days. Twenty cases of verruca vulgaris were treated with topical fluorouracil cream as above and 20 cases by electrodessication. The cure rate was graded as 'Good' with 100% cure, 'Moderate' -upto 50%, "Poor' -no or little re­sponse.

  Results Top

Condylomata accuminata group : Twenty cases (80%) showed disappearance of all warts, 3 (12%) cases showed moderate response and 2 (8%) cases failed to respond with flurouracil cream. Two (8%) cases had recurrence. Of the 20 cases treated with 25% podophyllin, 13 cases (65%) showed 'Good' response, 7 (35%) cases showed moderate response and 4 (20%) cases showed recurrence.

Verruca vulgaris group : Six (30%) showed 'Good' response while 10 (50%) showed only 'Moderate' response and 4(20%) cases showed 'Poor' response with 5% 5 flurouracil cream. No recurrence was observed in 'Good' response cases. 20 (100%) cases treated with electrodessication showed initial good response, but 6 (30%) cases had recurrence.

  Side effect Top

Moderate excoriation and oedema of sur­rounding area was seen in 4 (20%) cases of genital warts.

  Comments Top

Topical fluorouracil cream was found su­perior to podophyllin in condylomata accuminata both in response to therapy and also in pre­venting recurrence. It was less effective in the treatment of verruca vulgaris.

  References Top

1.Kinghom G R : Genital papilloma virus infection treatment, Recent Advances in Sexually Trans­mitted Diseases No. 3, editors, Oriel JD and Harris J R, 1986, 147-150  Back to cited text no. 1    
2.Hurst house MW : A controlled trial on the use of toopical 5 fluorouracil on viral warts; Brit J Dermatol, 1978; 93:93-96  Back to cited text no. 2    
3.Von Krogh G : Penile condylomata accuminate an experimental model for evaluation of topical treat­ment with 0.5% - 1% ethanolic preparation of podophyllotoxin for 3 days, Sex Trans Dis, 1981; 8:179-186  Back to cited text no. 3    

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1 Comparative efficacy of topical 5% 5-fluorouracil with electrosurgery in treatment of warts
Dogra, A., Gupta, S., Bansal, A.
Indian Journal of Dermatology. 2006; 51(2): 108-110


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