|Year : 1991 | Volume
| Issue : 1 | Page : 51
Evaluation of 5-fluorouracil in treatment of warts
SP Chattopadhyay, PK Das
S P Chattopadhyay
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Chattopadhyay S P, Das P K. Evaluation of 5-fluorouracil in treatment of warts. Indian J Dermatol Venereol Leprol 1991;57:51
|How to cite this URL:|
Chattopadhyay S P, Das P K. Evaluation of 5-fluorouracil in treatment of warts. Indian J Dermatol Venereol Leprol [serial online] 1991 [cited 2020 Jul 15];57:51. Available from: http://www.ijdvl.com/text.asp?1991/57/1/51/3625
Electrodessication is one of the foremost method for treatment of verruca vulgaris but it produces scars and recurrences. Condylomata accuminata is usually treated with 25% podophyllin with painful ulceration & variability in response and recurrence.
In this study topical 5% 5 fluorouracil cream was evaluated. Fluorouracil is flurinated pyrimidine and it interfers with DNA synthesis by decreasing the availability of thiamine. In a double blind study 5% 5 fluorouracil was found superior to placebo in the treatment of verruca vulgaris. By applying 5% 5 fluorouracil twice daily for 3 weeks a cure rate of 25% for meatal warts, 36% for preputial and 71% for penile skin warts was achieved.
| Material and Methods|| |
Out of fifty cases of condylomata accuminata selected at random, 25 cases were treated with topical 5% 5 fluorouracil USP in cream base for 8 hours daily for 2-3 weeks. The remaining 25 cases were treated with 25% podophyllin in Tinc benzoin for 8 hours for 2 days. Twenty cases of verruca vulgaris were treated with topical fluorouracil cream as above and 20 cases by electrodessication. The cure rate was graded as 'Good' with 100% cure, 'Moderate' -upto 50%, "Poor' -no or little response.
| Results|| |
Condylomata accuminata group : Twenty cases (80%) showed disappearance of all warts, 3 (12%) cases showed moderate response and 2 (8%) cases failed to respond with flurouracil cream. Two (8%) cases had recurrence. Of the 20 cases treated with 25% podophyllin, 13 cases (65%) showed 'Good' response, 7 (35%) cases showed moderate response and 4 (20%) cases showed recurrence.
Verruca vulgaris group : Six (30%) showed 'Good' response while 10 (50%) showed only 'Moderate' response and 4(20%) cases showed 'Poor' response with 5% 5 flurouracil cream. No recurrence was observed in 'Good' response cases. 20 (100%) cases treated with electrodessication showed initial good response, but 6 (30%) cases had recurrence.
| Side effect|| |
Moderate excoriation and oedema of surrounding area was seen in 4 (20%) cases of genital warts.
| Comments|| |
Topical fluorouracil cream was found superior to podophyllin in condylomata accuminata both in response to therapy and also in preventing recurrence. It was less effective in the treatment of verruca vulgaris.
| References|| |
|1.||Kinghom G R : Genital papilloma virus infection treatment, Recent Advances in Sexually Transmitted Diseases No. 3, editors, Oriel JD and Harris J R, 1986, 147-150 |
|2.||Hurst house MW : A controlled trial on the use of toopical 5 fluorouracil on viral warts; Brit J Dermatol, 1978; 93:93-96 |
|3.||Von Krogh G : Penile condylomata accuminate an experimental model for evaluation of topical treatment with 0.5% - 1% ethanolic preparation of podophyllotoxin for 3 days, Sex Trans Dis, 1981; 8:179-186 |
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