|Year : 1990 | Volume
| Issue : 2 | Page : 123-124
Study of thirty three cases of fixed drug eruption
KK Singh, CR Srinivas, DS Krupashankar, RPC Naik
K K Singh
Source of Support: None, Conflict of Interest: None
Out of 33 patients, clinically diagnosed as FDE, 16 had positive provocation test. Eight patients had reacted to cotrimoxazole, 4 to oxyphenbutazone, 2 to both tetracycline and doxycycline and one each to rifampicin and griseofulvin. All genital FDE were exclusively caused by cotrimoxazole.
Keywords: Fixed drug eruption, Provocation test
|How to cite this article:|
Singh K K, Srinivas C R, Krupashankar D S, Naik R. Study of thirty three cases of fixed drug eruption. Indian J Dermatol Venereol Leprol 1990;56:123-4
|How to cite this URL:|
Singh K K, Srinivas C R, Krupashankar D S, Naik R. Study of thirty three cases of fixed drug eruption. Indian J Dermatol Venereol Leprol [serial online] 1990 [cited 2020 May 29];56:123-4. Available from: http://www.ijdvl.com/text.asp?1990/56/2/123/3499
Fixed drug eruption (FDE) appears as an oval, erythematous patch and recurs at the same areas following every administration of the responsible drug. FDE is most commonly seen with tetracycline, analgin and oxyphenbutazone.' Phenolphthalein has also been incriminated as a common cause of FDE.,
Although a large number of drugs have been incriminated to cause FDE, certain drugs are more often responsible for causing the same. Limbs and trunk are most commonly affected, but involvement of glans penis and lips is not uncommon.,
| Materials and Methods|| |
Thirty three patients with the clinical diagnosis of FDE were interrogated regarding the onset, duration and drugs taken for any specific complaints. The provocation- test was started with a quarter of a single therapeutic dose, followed if necessary by a step-wise increase to one half, one full dose and the double of a dose. Provocation was considered negative if exacerbation of the lesion was not seen within 24 hours after even the double dose. Erythema, itching and burning around the existing macule were taken to indicate a positive provocation test. The drugs used for provocation included cotrimoxazole, oxyphenbutazone, tetracycline, doxycycline, rifampicin, griseofulvin, analgin, aspirin, paracetamol and ibuprofen.
| Results|| |
There were 33 patients (29 men and 4 women) with a mean age of 34.1 years. The duration of the disease ranged from 10 days to 7 years. The lesions had characteristic features. Three cases of genital FDE had superficial erosions. Genitalia (8 patients), oral mucosa (6), lower extremities (4), upper extremities (2), trunk (2) and. buttock (1) were the affected sites. Sixteen patients (15 men and one woman) had positive provocation test. Cotrimoxazole caused all the genital lesions in this study. [Table - 1] shows the number of cases caused by various drugs.
| Comments|| |
The list of common drugs responsible for FDE does not remain valid because of newers additions, variations in use and availability from place to place. Cotrimoxazole topped the list in the present series. It has been observed as a common offending agent by others also., The patients are often ignorant of the drugs consumed and often do not accept it as the etiologic factor. A detailed drug history as well as the complaints for which the drug is taken is helpful before undertaking the provocation test. Sometimes FDE can be caused by rare drugs. There is only one previous case of FDE caused by griseofulvin Atypical FDE due to azathioprine and rifampicin has also been reported.
Seventeen of our patients showed no reaction following the provocation test. Probably provocation with more drugs was necessary to trace out the actual drug.
| References|| |
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|3.||Wintroub BU, Shiffman NJ and Arndt KA Fixed drug eruptions, in : Dermatology in General Medicine, Second ed, Editors, Fitzpatrick TB, Eisen A?, Wolff K et al : Me Graw-Hill Book Company, New York, 1979; p 562. |
|4.||Baker H : Fixed eruptions, in : Text Book of Dermatology, Third ed, Editors, Rook A, Wilkinson DS and Ebling FJG : Blackwell Scientific Publications, Oxford, 1979; p 1121-1122. |
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|6.||Thyaraian K, Kamalam A and Thambiah AS Fixed drug eruption to griseofulvin, Mykosen, 1981; 8 : 462-464. |
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[Table - 1]
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