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ORIGINAL CONTRIBUTIONS
Year : 1990  |  Volume : 56  |  Issue : 2  |  Page : 107-108

Evaluaton of vinca rosea for the threatment of warts




Correspondence Address:
S P Chattopadhyay


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Source of Support: None, Conflict of Interest: None


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  Abstract 

Nineteen cases of warts of various types (flat 3, veffuca vulgaris 8, planter warts.3 and genital warts 5) were treated with applications of Vinca rosea cream twice a day 1-2 hours after application of an ointment containing equal parts of 5% salicylic acid and 0.0.5% tretinoin (1:1). The response after 6 weeks of treatment when compared with a control group of 14 cases of various types of warts applying only 5% saliylic acid and 0.05% tretinoin (1:1) was found to be better in clearing the warts and also preventing recurrences.


Keywords: Warts, Vinca rosea cream, Treatment


How to cite this article:
Chattopadhyay S P, Das P K. Evaluaton of vinca rosea for the threatment of warts. Indian J Dermatol Venereol Leprol 1990;56:107-8

How to cite this URL:
Chattopadhyay S P, Das P K. Evaluaton of vinca rosea for the threatment of warts. Indian J Dermatol Venereol Leprol [serial online] 1990 [cited 2020 Jul 2];56:107-8. Available from: http://www.ijdvl.com/text.asp?1990/56/2/107/3493


Most modalities for the treatment of warts do not give consistently satisfactory results. Warts often recur after an apparent cure or do not disappear after local treatment. Benign nature of warts demands that the treatment should not produce any disability. Electro­dessication of warts, chemo-surgery or cryo­surgery may produce scars. Due to the non­specific action of the agents, none of these gives uniform results.

Vinca rosea (a common Indian plant Sada Bahat) has been mentioned for the treatment of blood pressure, diabetes mellitus etc in medicinal folk-lores[1] and the Indian system of medicine.[2] Noble and associates could not substantiate its antidiabetic effects but observed granulocytopenia and bone marrow depression after administration of vinca alkaloids.[3] Subsequently, two important alkaloids vincri­stine and vinblastine have been isolated and recommended for their use in leukemia and lymphoma group of diseases.[4] No data is available on the efficacy of vinca alkaloids as topical agents for the treatment of warts. A study was therefore carried out to evaluate the effectiveness of vinca alkaloids obtained from extracts of Vinca rosea plant for the treatment of warts.


  Materials and Methods Top


The patients having warts were divided into four groups namely verruca vulgaris (8), plantar warts (3), flat warts (3) and genital warts (5). The leaves and the bark of Vinca rosea plant were dried, powdered and mixed in equal quantities and then suspended in an equal volume of polyethylene glycol (400) to form a cream. This was used for local applications twice daily on the wart. To facilitate penetration of the vinca alkaloids to the warts tissue, an ointment containing equal parts of 5% salicylic acid in petrolatum base and 0.05% tretinoin was applied 1-2 hours earlier.

As a control, 14 cases were treated with 5% salicylic acid in petrolatum and 0.05% tretinoin mixed in 1 : 1 ratio. The total duration of the treatment in both the groups extended for a maximum period of 6 weeks, the duration depending on the clinical response. All cases were followed up for a minimum period of 6 months. Vinea rosea cream was also applied after treatment with electrodessication and 25% podophyllin application in cases who did not respond fully in either group.


  Results Top


Of the 19 cases in the test group, 6 (31.5%) cases showed a very good response in that all the waits disappeared, 7 (36.8%,) cases showed a good response where majority of the warts had disappeared, 5 (26.4%) cases showed a moderate; response with disappearance of 50% of the waits, while 1 (5.3%) case showed no response. Recurrence was seen in 1 (5.3) case.

In the control group (14 patients), 1 (7.2%) case showed a very good response, 3 (21.4%) cases showed a good response, 2 (14.2%) cases showed a modetate response, while in 8 (57.2%) cases, the i esponse was poor.
  Comments Top


Vinea rosea cream was more effective for the treatment of verruca vulgaris, plantar warts and flat warts and less effective in the genital warts. It also prevented recurrences in a majority of the cases when applied alone or after electrodessication and 25% podophyllin application in non-genital and genital warts respectively.


  Acknowledgement Top


This study was carried out with a grant from the Armed Forces Medical Research Committee, India.

 
  References Top

1.Gilman AG, Goodman LS, Rall TW et al : Vinca alkaloids, in : The Pharmacological Basis of Thera­peutics, 7th ed, Macmillan, New York, 1985; p 1277.  Back to cited text no. 1    
2.Bhattacharya Shibakali : Nayantara (Sada Bahar), in : Chiranjeeva Vanaushadi, Vol 9, First ed, Ananda Publishers, Calcutta, 1988; p 3-7.  Back to cited text no. 2    
3.Noble RL., Beer CT and Cutis JET : Further biolo­gical activities of vincaleukoblastine an alkaloid isolated from Vinica rcsea, Biochem Pharmacol, 1958; 1, p 347-348.  Back to cited text no. 3    
4.Johnson IS, Amstrong JG, Gorman M et al : The vinca alkaloids-a new class of oncolytic agents, Cancer Res, 1963; 23 : p 1390-1427.  Back to cited text no. 4    




 

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