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Year : 1976  |  Volume : 42  |  Issue : 5  |  Page : 281--284

Beclomethasone Dipropionate Its Efficacy and Percutaneous Absorption in Psoriasis


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L K Bhutani


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Plasma cortical levels in 7 patients with psoriasis of variable severity were determined. Ten patients with extensive lesions (over 10% body surface area involved) were treated with topical application of 0.025% Beclomethasone dipropionate cream. The effect of Beclomethasone therapy on clinical condition and plasma col levels was assessed at weekly intervals for 3 weeks. Clinical improvement varying between 10-80% was seen in 4 patients; 5 patients complained of itching and burning sensation after 1-2 weeks of Beclomethasone therapy. One patient each developed pustular psoriasis and exfoliative dermatitis while on therapy. Plasma cortisol levels Were slightly elevated in 4 out of the 7 patients and application for 3 weeks of the Beclomediasone cream did not produce any depression in plasma cortisol levels in any patient.






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