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Year : 1974  |  Volume : 40  |  Issue : 4  |  Page : 181--184

Chemoprophylaxis in Pyodermas

Correspondence Address:
Gurmohan Singh

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Source of Support: None, Conflict of Interest: None

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Effect of prophylactic use of-antibiotics for preventing staphylococcal infections of skin was studied experimentally. Healthy human volunteers were given pencillin or demethylchlor tetracycline in usual therapeutic doses -and later challenged with staphylococci. In 2 of 3 subjects, the prophylactically given drug could not ;prevent the experimental infection, even though the challenging organisms were sensitive to the respective antibiotics in vitro. When the drug was continued even after the staphylococci were inoculated, 50% showed evidence of clinical infection. Diphtheroids had complete disappearance and staphylococcus epidermidis became resistant to the antibiotic used even though its quantum remained at a constant level.

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Online since 15th March '04
Published by Wolters Kluwer - Medknow